CREB and the CRTC co-activators: sensors for hormonal and metabolic signals
JY Altarejos, M Montminy - Nature reviews Molecular cell biology, 2011 - nature.com
The cyclic AMP-responsive element-binding protein (CREB) is phosphorylated in response
to a wide variety of signals, yet target gene transcription is only increased in a subset of …
to a wide variety of signals, yet target gene transcription is only increased in a subset of …
Time-resolved analysis reveals rapid dynamics and broad scope of the CBP/p300 acetylome
The acetyltransferases CBP and p300 are multifunctional transcriptional co-activators. Here,
we combined quantitative proteomics with CBP/p300-specific catalytic inhibitors …
we combined quantitative proteomics with CBP/p300-specific catalytic inhibitors …
Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits
Tauopathies, including frontotemporal dementia (FTD) and Alzheimer's disease (AD), are
neurodegenerative diseases in which tau fibrils accumulate. Recent evidence supports …
neurodegenerative diseases in which tau fibrils accumulate. Recent evidence supports …
Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer
M Peifer, L Fernández-Cuesta, ML Sos, J George… - Nature …, 2012 - nature.com
Small-cell lung cancer (SCLC) is an aggressive lung tumor subtype with poor prognosis,,.
We sequenced 29 SCLC exomes, 2 genomes and 15 transcriptomes and found an …
We sequenced 29 SCLC exomes, 2 genomes and 15 transcriptomes and found an …
Epigenetic regulation of melanogenesis
S Zhou, H Zeng, J Huang, L Lei, X Tong, S Li… - Ageing research …, 2021 - Elsevier
Melanogenesis is a complex process in which melanin is synthesized in melanocytes and
transported to keratinocytes, which involves multiple genes and signaling pathways …
transported to keratinocytes, which involves multiple genes and signaling pathways …
Inactivating mutations of acetyltransferase genes in B-cell lymphoma
L Pasqualucci, D Dominguez-Sola, A Chiarenza… - Nature, 2011 - nature.com
B-cell non-Hodgkin's lymphoma comprises biologically and clinically distinct diseases the
pathogenesis of which is associated with genetic lesions affecting oncogenes and tumour …
pathogenesis of which is associated with genetic lesions affecting oncogenes and tumour …
Distinct roles of GCN5/PCAF‐mediated H3K9ac and CBP/p300‐mediated H3K18/27ac in nuclear receptor transactivation
Histone acetyltransferases (HATs) GCN5 and PCAF (GCN5/PCAF) and CBP and p300
(CBP/p300) are transcription co‐activators. However, how these two distinct families of HATs …
(CBP/p300) are transcription co‐activators. However, how these two distinct families of HATs …
CREBBP mutations in relapsed acute lymphoblastic leukaemia
CG Mullighan, J Zhang, LH Kasper, S Lerach… - Nature, 2011 - nature.com
Relapsed acute lymphoblastic leukaemia (ALL) is a leading cause of death due to disease
in young people, but the biological determinants of treatment failure remain poorly …
in young people, but the biological determinants of treatment failure remain poorly …
TGF-β-Id1 signaling opposes Twist1 and promotes metastatic colonization via a mesenchymal-to-epithelial transition
M Stankic, S Pavlovic, Y Chin, E Brogi, D Padua… - Cell reports, 2013 - cell.com
ID genes are required for breast cancer colonization of the lungs, but the mechanism
remains poorly understood. Here, we show that Id1 expression induces a stem-like …
remains poorly understood. Here, we show that Id1 expression induces a stem-like …