Type 1 diabetes (T1D) is an autoimmune disease characterized by autoreactive T cell-
mediated destruction of insulin-producing pancreatic beta-cells. Loss of beta-cells leads to …

Publisher Summary This chapter summarizes the experimental findings and observations
based on the nonobese diabetic (NOD) mouse model and discusses the pathogenesis and …

The nonobese diabetic mouse is recognized as an important animal model for human
insulin-dependent diabetes mellitus. One of the components of susceptibility to this disease …

Nonobese diabetic (NOD) mice spontaneously develop an acute onset of hyperglycemia
reminiscent of human type I diabetes. The disease is the end result of a mononuclear cell …

The nonobese diabetic (NOD) mouse, a model of human type I diabetes, develops insulitis
beginning at 4–6 wk of age. By 30 wk of age, 72% of females and 39% of males develop …

The role of tumor necrosis factor alpha (TNF-alpha) in the pathogenesis of autoimmune
diabetes mellitus was tested in the nonobese mouse (NOD) model system. The effects of …

The nonobese diabetic (NOD) mouse is an excellent model of insulin-dependent (type I)
human diabetes mellitus. We report that a single injection of complete Freund's adjuvant …

Spontaneous diabetes mellitus was blocked in nonobese diabetic mice by treatment with a
monoclonal antibody against the L3T4 determinant present on the surface of T-helper …

INSULIN-dependent diabetes mellitus (IDDM) is a disease with an autoimmune aetiology.
The non-obese diabetic mouse is a good spontaneous animal model of the human disease …

The effects of Lactobacillus casei (LC) on the onset of diabetes in an insulin‐dependent
diabetes mellitus model, nonobese diabetic (NOD) mice, were examined. From the age of 4 …