An update on African trypanocide pharmaceutics and resistance

KI Kasozi, ET MacLeod, I Ntulume… - Frontiers in Veterinary …, 2022 - frontiersin.org
African trypanosomiasis is associated with Trypanosoma evansi, T. vivax, T. congolense,
and T. brucei pathogens in African animal trypanosomiasis (AAT) while T. b gambiense and …

Pathogenicity and virulence of African trypanosomes: From laboratory models to clinically relevant hosts

LJ Morrison, PC Steketee, MD Tettey, KR Matthews - Virulence, 2023 - Taylor & Francis
African trypanosomes are vector-borne protozoa, which cause significant human and animal
disease across sub-Saharan Africa, and animal disease across Asia and South America. In …

[HTML][HTML] Mapping diversity in African trypanosomes using high resolution spatial proteomics

NM Moloney, K Barylyuk, E Tromer, OM Crook… - Nature …, 2023 - nature.com
African trypanosomes are dixenous eukaryotic parasites that impose a significant human
and veterinary disease burden on sub-Saharan Africa. Diversity between species and life …

What is needed to achieve effective and sustainable control of African animal trypanosomosis?

LJ Morrison, MP Barrett, PC Steketee, G Cecchi… - Trends in …, 2024 - cell.com
A welcome resurgence in African animal trypanosomosis (AAT) research has resulted in
advances in capabilities, foundational datasets, and understanding. Additionally, there is the …

Fatty acid uptake in Trypanosoma brucei: Host resources and possible mechanisms

NR Poudyal, KS Paul - Frontiers in cellular and infection microbiology, 2022 - frontiersin.org
Trypanosoma brucei spp. causes African Sleeping Sickness in humans and nagana, a
wasting disease, in cattle. As T. brucei goes through its life cycle in its mammalian and insect …

Cloning and Characterization of Trypanosoma congolense and T. vivax Nucleoside Transporters Reveal the Potential of P1-Type Carriers for the Discovery of Broad …

MA Ungogo, MM Aldfer, MJ Natto, H Zhuang… - International journal of …, 2023 - mdpi.com
African Animal Trypanosomiasis (AAT), caused predominantly by Trypanosoma brucei
brucei, T. vivax and T. congolense, is a fatal livestock disease throughout Sub-Saharan …

Mitochondrial adaptations throughout the Trypanosoma brucei life cycle

A Zíková - Journal of Eukaryotic Microbiology, 2022 - Wiley Online Library
The unicellular parasite Trypanosoma brucei has a digenetic life cycle that alternates
between a mammalian host and an insect vector. During programmed development, this …

[HTML][HTML] Drug resistance in animal trypanosomiases: Epidemiology, mechanisms and control strategies

MA Ungogo, HP de Koning - … Journal for Parasitology: Drugs and Drug …, 2024 - Elsevier
Animal trypanosomiasis (AT) is a complex of veterinary diseases known under various
names such as nagana, surra, dourine and mal de caderas, depending on the country, the …

Recent advances in genome editing of bloodstream forms of Trypanosoma congolense using CRISPR-Cas9 ribonucleoproteins: Proof of concept

C Minet, I Chantal, D Berthier - Experimental Parasitology, 2023 - Elsevier
Abstract African Animal Trypanosomosis (AAT or Nagana) is a vector-borne disease caused
by Trypanosomatidae, genus Trypanosoma. The disease is transmitted by the bite of …

[HTML][HTML] Anti-parasitic benzoxaboroles are ineffective against Theileria parva in vitro

PC Steketee, E Paxton, MP Barrett, MC Pearce… - International Journal for …, 2023 - Elsevier
Abstract East Coast Fever (ECF) is a disease affecting cattle in sub-Saharan Africa, caused
by the tick-borne Apicomplexan pathogen Theileria parva. The disease is a major problem …