Colistin regained global interest as a consequence of the rising prevalence of multidrug-
resistant Gram-negative Enterobacteriaceae. In parallel, colistin-resistant bacteria emerged …

Polymyxins are well-established antibiotics that have recently regained significant interest
as a consequence of the increasing incidence of infections due to multidrug-resistant Gram …

Colistin represents one of the few available drugs for treating infections caused by
carbapenem-resistant Enterobacteriaceae. As such, the recent plasmid-mediated spread of …

Colistin is an effective antibiotic for treatment of most multidrug-resistant Gram-negative
bacteria. It is used currently as a last-line drug for infections due to severe Gram-negative …

In the past years infections caused by multidrug-resistant Gram-negative bacteria have
dramatically increased in all parts of the world. This consensus paper is based on …

Antibiotic resistance has become a global public health priority. Polymyxins, a family of
cationic polypeptide antibiotics, act as a final line of refuge against severe infections by …

Antibiotic resistance is a natural feature of diverse microbial ecosystems. Although recent
studies of the antibiotic resistome have highlighted barriers to the horizontal transfer of …

Resistance threatens to render antibiotics—which are essential for modern medicine—
ineffective, thus posing a threat to human health. The discovery of novel classes of …

Carbapenems, our one-time silver bullet for multidrug resistant bacterial infections, are now
threatened by widespread dissemination of carbapenem-resistant Enterobacteriaceae …

Colistin, also referred to as polymyxin E, is an effective antibiotic against most multidrug-
resistant Gram-negative bacteria and is currently used as a last-line drug for treating severe …