Members of the antiapoptotic BCL-2 proteins are involved in tumor growth, progression and
survival, and are also responsible for chemoresistance to conventional anticancer agents …

The anti-apoptotic Bcl-2 family is intrinsically involved in regulating apoptosis. Over
expression of these proteins is associated with cancer. Thus, inhibitors of these proteins will …

Deregulation of the normal cellular apoptotic function is a fundamental element in the
etiology of most cancers and the anti-apoptotic B cell lymphoma 2 (BCL‑2) protein family is …

Epidermal growth factor receptor (EGFR), a transmembrane glycoprotein, is overexpressed
in many cancers such as head-neck, breast, prostate, and skin cancers for this reason it is a …

Inhibition of normal cellular apoptosis or programed cell death is the hallmark of all cancers.
Apoptotic dysregulation can result in numerous pathological conditions, such as cancers …

COVID-19 is caused by SARS-CoV-2 and responsible for the ongoing global pandemic in
the world. After more than a year, we are still in lurch to combat and control the situation …

The proteins of Bcl-2 family, which are promising anti-cancer-drug targets, have substantial
similarity in primary sequence and share homologous domains as well as similar structural …

Bcl‐xl protein has a long unstructured loop attached to its structured region which joins two
helices. The necessity to have this unstructured segment in Bcl‐xl is not yet well understood …

Frequent mutations in the Bcl‐2 anti‐apoptotic protein are often implicated in diffuse large B‐
cell lymphoma (DLBCL), a disease profoundly resistant to drugs. Bcl‐2‐competitive …

Inhibition of normal cellular apoptosis or programed cell death is the hallmark of all cancers.
Apoptotic dysregulation can result in numerous pathological conditions, such as cancers …