Multidrug resistance proteins (MRPs): Structure, function and the overcoming of cancer multidrug resistance
ATP-binding cassette (ABC) transporters mediate the ATP-driven translocation of structurally
and mechanistically distinct substrates against steep concentration gradients. Among the …
and mechanistically distinct substrates against steep concentration gradients. Among the …
[HTML][HTML] Carleman estimates for semi-discrete parabolic operators and application to the controllability of semi-linear semi-discrete parabolic equations
F Boyer, J Le Rousseau - Annales de l'Institut Henri Poincare (C) Non …, 2014 - Elsevier
In arbitrary dimension, in the discrete setting of finite-differences we prove a Carleman
estimate for a semi-discrete parabolic operator, in which the large parameter is connected to …
estimate for a semi-discrete parabolic operator, in which the large parameter is connected to …
Hydrolysis of 2′ 3′-cGAMP by ENPP1 and design of nonhydrolyzable analogs
Agonists of mouse STING (TMEM173) shrink and even cure solid tumors by activating innate
immunity; human STING (hSTING) agonists are needed to test this therapeutic hypothesis in …
immunity; human STING (hSTING) agonists are needed to test this therapeutic hypothesis in …
ABC transporters in cancer: more than just drug efflux pumps
JI Fletcher, M Haber, MJ Henderson… - Nature Reviews Cancer, 2010 - nature.com
Multidrug transporter proteins are best known for their contributions to chemoresistance
through the efflux of anticancer drugs from cancer cells. However, a considerable body of …
through the efflux of anticancer drugs from cancer cells. However, a considerable body of …
ATP‐binding cassette (ABC) transporters in cancer: A review of recent updates
The ATP‐binding cassette (ABC) transporter superfamily is one of the largest membrane
protein families existing in wide spectrum of organisms from prokaryotes to human. ABC …
protein families existing in wide spectrum of organisms from prokaryotes to human. ABC …
Advances in therapeutic interventions for patients with pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) is a disease characterized by progressive
remodeling of the distal pulmonary arteries, resulting in the loss of vascular cross-sectional …
remodeling of the distal pulmonary arteries, resulting in the loss of vascular cross-sectional …
Renal drug transporters and drug interactions
Transporters in proximal renal tubules contribute to the disposition of numerous drugs.
Furthermore, the molecular mechanisms of tubular secretion have been progressively …
Furthermore, the molecular mechanisms of tubular secretion have been progressively …
[HTML][HTML] The blood-brain barrier in brain homeostasis and neurological diseases
N Weiss, F Miller, S Cazaubon, PO Couraud - Biochimica et Biophysica …, 2009 - Elsevier
Brain endothelial cells are unique among endothelial cells in that they express apical
junctional complexes, including tight junctions, which quite resemble epithelial tight …
junctional complexes, including tight junctions, which quite resemble epithelial tight …
Transmembrane transport of endo-and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins
Multidrug Resistance Proteins (MRPs), together with the cystic fibrosis conductance
regulator (CFTR/ABCC7) and the sulfonylurea receptors (SUR1/ABCC8 and SUR2/ABCC9) …
regulator (CFTR/ABCC7) and the sulfonylurea receptors (SUR1/ABCC8 and SUR2/ABCC9) …
[HTML][HTML] Multidrug resistance associated proteins in multidrug resistance
Multidrug resistance proteins (MRPs) are members of the C family of a group of proteins
named ATP-binding cassette (ABC) transporters. These ABC transporters together form the …
named ATP-binding cassette (ABC) transporters. These ABC transporters together form the …