Many of the motor symptoms of Parkinson disease (PD) can be preceded, sometimes for
several years, by non-motor symptoms that include hyposmia, sleep disorders, depression …

Parkinson's disease (PD) is a complex, multi-system neurodegenerative disorder. The
second most common neurodegenerative disorder after Alzheimer's disease, it affects …

Recent work continues to place cholinergic circuits at center stage for normal executive and
mnemonic functioning and provides compelling evidence that the loss of cholinergic …

Synucleinopathies, such as Parkinson's disease and dementia with Lewy bodies, are
neurodegenerative disorders that are characterized by the accumulation of α-synuclein …

Degeneration of central cholinergic neurons impairs memory, and enhancement of
cholinergic synapses improves cognitive processes. Cholinergic signaling is also anti …

The recent formalization of clinical criteria for Parkinson's disease with dementia (PDD)
codifies many studies on this topic, including those assessing biological correlates. These …

Identification of mutations that cause rare familial forms of Parkinson's disease (PD) and
subsequent studies of genetic risk factors for sporadic PD have led to an improved …

The novel object recognition test (NOR) test is a two trial cognitive paradigm that assesses
recognition memory. Recognition memory is disturbed in a range of human disorders and …

Parkinson's disease (PD) is classically characterized by motor symptoms; however, non-
motor symptoms (NMS) are increasingly recognized as relevant in disease-state, given the …

Parkinson's disease (PD) is the most common neurodegenerative movement disorder, yet
disease-modifying treatments do not currently exist. Rho-associated protein kinase (ROCK) …