Viruses infecting vertebrate hosts must overcome the interferon (IFN)-mediated antiviral
response to replicate and propagate to new hosts. The complex regulation of the IFN …

The current outbreak of monkeypox (MPX) infection has emerged as a global matter of
concern in the last few months. MPX is a zoonosis caused by the MPX virus (MPXV), which …

Poxviruses have evolved a wide array of mechanisms to evade the immune response, and
we provide an overview of the different immunomodulatory strategies. Poxviruses prevent …

Cancer vaccines and oncolytic immunotherapy are promising treatment strategies with
potential to provide greater clinical benefit to patients with advanced-stage cancer. In …

Modulation of the antiviral innate immune response has been proposed as a putative
cellular target for the development of novel pan-viral therapeutic strategies. The Janus …

Infection of mammalian cells with viruses activates NF-κB to induce the expression of
cytokines and chemokines and initiate an antiviral response. Here, we show that a vaccinia …

Monkeypox virus (MPXV) is a DNA virus belonging to the Orthopoxvirus genus within the
Poxviridae family which can cause a zoonotic infection. The unexpected non-endemic …

Re-emerging and new viral pathogens have caused significant morbidity and mortality
around the world, as evidenced by the recent monkeypox, Ebola and Zika virus outbreaks …

The interferon (IFN)-stimulated gene 15 (ISG15) encodes one of the most abundant proteins
induced by interferon, and its expression is associated with antiviral immunity. To identify …

African swine fever (ASF) is an acute and severe infectious disease caused by the ASF virus
(ASFV). The mortality rate of ASF in pigs can reach 100%, causing huge economic losses to …