Recent advances in Sonogashira reactions

R Chinchilla, C Nájera - Chemical Society Reviews, 2011 - pubs.rsc.org
The coupling of aryl or vinyl halides with terminal acetylenes catalysed by palladium and
other transition metals, commonly termed as Sonogashira cross-coupling reaction, is one of …

Synthesis of symmetrical and unsymmetrical diarylalkynes from propiolic acid using palladium-catalyzed decarboxylative coupling

K Park, G Bae, J Moon, J Choe… - The Journal of Organic …, 2010 - ACS Publications
Symmetrical diarylalkynes were obtained from propiolic acid (or 2-butynedioic acid) and aryl
halides in good yields. The optimized reaction conditions were 2.0 equiv of aryl halide, 1.0 …

Transition metal-catalyzed alkynylation reactions via alkynyl carbon–carbon bond cleavage

H Yuan, Q Zhou, J Wang - Organic Chemistry Frontiers, 2023 - pubs.rsc.org
It is of great significance to realize the alkynylation of the reaction since alkynes are widely
present in natural products and biologically active molecules. And at the same time alkynes …

Heck Alkynylation (Copper-Free Sonogashira Coupling) of Aryl and Heteroaryl Chlorides, Using Pd Complexes of t-Bu2(p-NMe2C6H4)P: Understanding the …

X Pu, H Li, TJ Colacot - The Journal of Organic Chemistry, 2013 - ACS Publications
L2Pd (0) and L2Pd (II) complexes, where L= t-Bu2 (p-NMe2C6H4) P, have been identified
as efficient catalyst systems for the Heck alkynylation of a variety of aryl bromides (17 …

Palladacycle-catalyzed deacetonative sonogashira coupling of aryl propargyl alcohols with aryl chlorides

H Hu, F Yang, Y Wu - The Journal of Organic Chemistry, 2013 - ACS Publications
An efficient and general protocol for the deacetonative Sonogashira coupling of aryl
propargyl alcohols with aryl chlorides is described. The reaction proceeded smoothly with …

One-pot procedure for the synthesis of unsymmetrical diarylalkynes

R Severin, J Reimer, S Doye - The Journal of Organic Chemistry, 2010 - ACS Publications
Unsymmetrical diarylalkynes are accessible by a one-pot procedure from two different aryl
halides and (trimethylsilyl) acetylene. The three-component coupling is initialized by a …

Efficient copper-free Sonogashira coupling of aryl chlorides with palladium on charcoal

A Komáromi, Z Novák - Chemical communications, 2008 - pubs.rsc.org
Efficient copper-free Sonogashira coupling of aryl chlorides with palladium on charcoal -
Chemical Communications (RSC Publishing) DOI:10.1039/B810928A Royal Society of …

Copper-free Sonogashira coupling in amine–water solvent mixtures

A Komáromi, GL Tolnai, Z Novák - Tetrahedron Letters, 2008 - Elsevier
Extensive study of different amine–water solvent mixtures was carried out for copper free
Sonogashira coupling of aryl iodides. The influence of the palladium sources, ligands …

Copper-catalyzed deacetonative Sonogashira coupling

YN Kotovshchikov, AA Binyakovsky… - Organic & …, 2022 - pubs.rsc.org
A convenient Pd-and phosphine-free protocol for assembling internal alkynes from tertiary
propargyl alcohols and (het) aryl halides has been developed. The proposed tandem …

One‐Pot Domino Synthesis of Diarylalkynes/1, 4‐Diaryl‐1, 3‐diynes by [9, 9‐Dimethyl‐4, 5‐bis (diphenylphosphino) xanthene](Xantphos)–Copper (I) Iodide …

S Qiu, C Zhang, R Qiu, G Yin… - Advanced Synthesis & …, 2018 - Wiley Online Library
The low loading combination of the complex [9, 9‐dimethyl‐4, 5‐bis (diphenylphosphino)
xanthene](Xantphos) copper (I) iodide and simple ligand‐free palladium (II) acetate was …