The use of photochemical transformations is a powerful strategy that allows for the formation
of a high degree of molecular complexity from relatively simple building blocks in a single …

Historically, natural products have been used since ancient times and in folklore for the
treatment of many diseases and illnesses. Classical natural product chemistry …

Covering: 2008–2013. Previous review: 2008, 25, 475 There are a significant number of
natural product (NP) drugs in development. We review the 100 NP and NP-derived …

Since ancient times, natural products from plants, animals, microbial and marine sources
have been exploited for treatment of several diseases. The knowledge of our ancestors is …

Abstract Analysis of the origins of new drugs approved by the US Food and Drug
Administration (FDA) from 1999 to 2008 suggested that phenotypic screening strategies had …

The pool of abundant chiral terpene building blocks (ie,“chiral pool terpenes”) has long
served as a starting point for the chemical synthesis of complex natural products, including …

Organic compounds from terrestrial and marine organisms have extensive past and present
use in the treatment of many diseases and serve as compounds of interest both in their …

Covering: 2005 to 2007 Natural product and natural product-derived compounds that are
being evaluated in clinical trials or are in registration (as at 31st December 2007) have been …

Background Actinic keratosis is a common precursor to sun-related squamous-cell
carcinoma. Treating actinic keratoses and the surrounding skin area (ie, field therapy) can …

Reactivation of a silent transcriptional program is a critical step in successful axon
regeneration following injury. Yet how such a program is unlocked after injury remains …