Simple Summary Sialylation is the synthetic process of sialoglycans, which are important in
tumor transformation, proliferation, metastasis, and immune evasion. The primary subjects of …

Sialic acids, commonly found as the terminal carbohydrate on the glycocalyx of mammalian
cells, are pivotal checkpoint inhibitors of the innate immune system, particularly within the …

Sialic acids are predominantly found at the terminal ends of glycoproteins and glycolipids
and play key roles in cellular communication and function. The process of sialylation, a form …

Simple Summary In addition to their function as energy sources, monosaccharides are used
to build complex structured oligo-and polysaccharides, which play numerous essential roles …

The biological heterogeneity of glioblastoma, IDH-wildtype (GBM, CNS WHO grade 4), the
most aggressive type of brain cancer, is a critical hallmark, caused by changes in the …

Oxidative stress represents a hallmark for many degenerative pathologies of the Central
Nervous System. Throughout life, the constant pressure of noxious stimuli and/or episodes …

Glioblastoma (GBM) is a highly aggressive brain tumor that often utilizes aerobic glycolysis
for energy production (Warburg effect), resulting in increased methylglyoxal (MGO) …

Sialic acids cap glycans displayed on mammalian glycoproteins and glycolipids and
mediate many glycan-receptor interactions. Sialoglycans play a role in diseases such as …

Sialylation is an enzymatic process that covalently attaches sialic acids to glycoproteins and
glycolipids and terminates them by creating sialic acid-containing glycans (sialoglycans) …