Schizophrenia has been primarily associated with dopamine dysfunction, and treatments
have been developed that target the dopamine pathway in the central nervous system …

Schizophrenia (SZ) is a devastating psychiatric disorder affecting about 1% of the world's
population. Social-cognitive impairments in SZ prevent positive social interactions and lead …

Cognitive deficits represent a major burden of neuropsychiatric disorders and result in part
from abnormal communication within hippocampal–prefrontal circuits. While it has been …

All currently approved drugs for schizophrenia work mainly by dopaminergic antagonism.
While they are efficacious for psychotic symptoms, their efficacy is limited for negative …

Summary Chromosome 16p11. 2 duplications dramatically increase risk for schizophrenia,
but the mechanisms remain largely unknown. Here, we show that mice with an equivalent …

Abstract The 15q13. 3 microdeletion copy number variation is strongly associated with
schizophrenia and epilepsy. The CHRNA7 gene, encoding nicotinic acetylcholine alpha 7 …

Aim The clinical features of schizophrenia can be mainly divided into two symptom domains:
positive and negative. Patients in each symptom domain respond differently to treatments …

The connectome, which is largely underpinned by the network science and graph theoretical
approaches, is relevant to the field of neuropsychiatry and could be successfully used for the …

Alongside positive and negative symptomatology, deficits in working memory, attention,
selective learning processes, and executive function have been widely documented in …

Purpose Anesthesia is a major confounding factor in functional MRI (fMRI) experiments
attributed to its effects on brain function. Recent evidence suggests that parameters obtained …