Natural killer (NK) cells are the predominant innate lymphocyte subsets that mediate anti-
tumor and anti-viral responses, and therefore possess promising clinical utilization. NK cells …

Immune checkpoint inhibitors (ICI) revolutionized the field of immuno-oncology and opened
new avenues towards the development of novel assets to achieve durable immune control …

Natural killer group 2, member D (NKG2D) is an activating receptor present on the surface of
natural killer (NK) cells, some NKT cells, CD8+ cytotoxic T cells, γδ T cells, and under certain …

DNA damage, oncogene activation and excessive proliferation, chromatin modulations or
oxidative stress are all important hallmarks of cancer. Interestingly, all of these abnormalities …

According to the humoral theory of transplantation, antibodies cause allograft rejection.
Publications are cited showing that antibodies:(1) cause hyperacute kidney rejection,(2) …

The specificity of immunoglobulins and α/β T cell receptors (TCRs) provides a framework for
the molecular basis of antigen recognition. Yet, evolution has preserved a separate lineage …

We show that histone deacetylase (HDAC) inhibitors lead to functional expression of MHC
class I–related chain A and B (MICA/B) on cancer cells, making them potent targets for …

The human MHC class I chain-related genes (MICA and MICB) are located within the HLA
class I region of chromosome 6. Their organization, expression and products differ …

Psoriasis is an immunologically mediated skin disease linked to several different class I
major histocompatibility complex alleles. However, the phenotype of the pathogenic …

MICA are distant homologs of MHC class I molecules expressed in the normal intestinal
epithelium. They are ligands of the NKG2D activating receptor expressed on most γδ T cells …