Cancer immunogenomics is an emerging field that bridges genomics and immunology. The
establishment of large-scale genomic collaborative efforts along with the development of …

Neoantigens are newly formed peptides created from somatic mutations that are capable of
inducing tumor-specific T cell recognition. Recently, researchers and clinicians have …

The CD155/TIGIT axis can be co-opted during immune evasion in chronic viral infections
and cancer. Pancreatic adenocarcinoma (PDAC) is a highly lethal malignancy, and immune …

Several decades of research have convincingly shown that classical human leukocyte
antigen (HLA) loci bear signatures of natural selection. Despite this conclusion, many …

HLA molecules are expressed in almost all nucleated cells of the body. These molecules are
extremely variable and responsible for tissue specificity recognition. Precise HLA typing is …

Rheumatoid arthritis (RA) is an autoimmune disease with an unclear pathogenic
mechanism. However, it has been proven that the key underlying risk factor is a genetic …

Differences in SARS-CoV-2-specific immune responses have been observed between
individuals following natural infection or vaccination. In addition to already known factors …

To perform detailed fine-mapping of the major-histocompatibility-complex region, we
conducted next-generation sequencing (NGS)-based typing of the 33 human leukocyte …

The field of cancer neoantigen investigation has developed swiftly in the past decade.
Predicting novel and true neoantigens derived from large multi-omics data became difficult …

Tumor neoantigens are aberrant polypeptides produced by tumor cells as a result of
genomic mutations. They are also tumor-specific antigens (TSA). Neoantigens are more …