[HTML][HTML] Optimizing CRISPR/Cas9 precision: Mitigating off-target effects for safe integration with photodynamic and stem cell therapies in cancer treatment

JPJ Merlin, H Abrahamse - Biomedicine & Pharmacotherapy, 2024 - Elsevier
CRISPR/Cas9 precision genome editing has revolutionized cancer treatment by introducing
specific alterations to the cancer genome. But the therapeutic potential of CRISPR/Cas9 is …

[HTML][HTML] Combining Photodynamic Therapy and Targeted Drug Delivery Systems: Enhancing Mitochondrial Toxicity for Improved Cancer Outcomes

JPJ Merlin, A Crous, H Abrahamse - International journal of molecular …, 2024 - mdpi.com
Cancer treatment continues to be a substantial problem due to tumor complexities and
persistence, demanding novel therapeutic techniques. This review investigates the …

Advancing Photodynamic Therapy with Nano-Conjugated Hypocrellin: Mechanisms and Clinical Applications

SS Rajan, R Chandran… - International Journal of …, 2024 - Taylor & Francis
Hypocrellin-based photodynamic therapy (PDT) is developing as a viable cancer
therapeutic option, especially when enhanced by nanoconjugation. This review investigates …

Biomimetic Ghost Nanomedicine-Based Optotheranostics for Cancer

R Prasad, VGS Jyothi, N Kommineni, RT Bulusu… - Nano Letters, 2024 - ACS Publications
Theranostic medicine combines diagnostics and therapeutics, focusing on solid tumors at
minimal doses. Optically activated photosensitizers are significant examples owing to their …

Advances in cuproptosis harnessing copper-based nanomaterials for cancer therapy

C Dong, X Ma, Y Wang, T Chen, C Gao, X Ye… - Journal of Materials …, 2025 - pubs.rsc.org
Cuproptosis, a newly identified programmed cell death form, is characterized by the
excessive copper accumulation in cells, resulting in mitochondria damage and toxic protein …

Overcoming challenges in cancer treatment: Nano‐enabled photodynamic therapy as a viable solution

SS Rajan, R Chandran… - Wiley Interdisciplinary …, 2024 - Wiley Online Library
Cancer presents a formidable challenge, necessitating innovative therapies that maximize
effectiveness while minimizing harm to healthy tissues. Nanotechnology has emerged as a …

Nanocomplex hyaluronic acid/ganciclovir@ ZIF-8 for ganciclovir efficient delivery and targeted anti-KSHV treatment

F Li, C Liu, W Gu, Q Xu, D Li, D Cao, Z Liu - Cancer Nanotechnology, 2025 - Springer
Kaposi's sarcoma-associated herpesvirus (KSHV) infection can cause a variety of tumors
and is one of the leading causes of death in acquired immune deficiency syndrome (AIDS) …

Introduction to nanophototherapy

P Manivasagan, A Joe, HW Han, SH Seo… - Nanophototherapy, 2025 - Elsevier
Cancer and microbial infections are common diseases in our society. Despite many efforts to
develop novel therapeutic approaches, nanophototherapy has emerged as a new and …