Maternal macronutrient consumption and the developmental origins of metabolic disease in the offspring

SM Kereliuk, GM Brawerman, VW Dolinsky - International Journal of …, 2017 - mdpi.com
Recent research aimed at understanding the rise in obesity and cardiometabolic disease in
children suggests that suboptimal maternal nutrition conditions organ systems and …

The obesogenic effect of high fructose exposure during early development

MI Goran, K Dumke, SG Bouret, B Kayser… - Nature Reviews …, 2013 - nature.com
Obesogens are compounds that disrupt the function and development of adipose tissue or
the normal metabolism of lipids, leading to an increased risk of obesity and associated …

High-fructose diet in pregnancy leads to fetal programming of hypertension, insulin resistance, and obesity in adult offspring

AF Saad, J Dickerson, TB Kechichian, H Yin… - American Journal of …, 2016 - Elsevier
Background Consumption of fructose-rich diets in the United States is on the rise and
thought to be associated with obesity and cardiometabolic diseases. Objective We sought to …

Spexin improves adipose tissue inflammation and macrophage recruitment in obese mice

SE Gambaro, MG Zubiría, AP Giordano… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Spexin (SPX) is a novel adipokine related to many metabolic effects, such as gastrointestinal
movements, insulin and glucose homeostasis, lipid metabolism and energy balance. This …

Early life exposure to fructose and offspring phenotype: implications for long term metabolic homeostasis

DM Sloboda, M Li, R Patel, ZE Clayton, C Yap… - Journal of …, 2014 - Wiley Online Library
The consumption of artificially sweetened processed foods, particularly high in fructose or
high fructose corn syrup, has increased significantly in the past few decades. As such …

[HTML][HTML] Translational insights on developmental origins of metabolic syndrome: Focus on fructose consumption

WC Lee, KLH Wu, S Leu, YL Tain - biomedical journal, 2018 - Elsevier
Metabolic syndrome (MetS) is a highly prevalent complex trait despite recent advances in
pathophysiology and pharmacological treatment. MetS can begin in early life by so-called …

Fructose, pregnancy and later life impacts

TRH Regnault, S Gentili, O Sarr… - Clinical and …, 2013 - Wiley Online Library
Fructose is an increasingly common constituent of the Westernized diet due to cost and
production efficiencies. Although an integral component of our pre‐industrial revolution diet …

[HTML][HTML] Supplementation of bitter melon to rats fed a high-fructose diet during gestation and lactation ameliorates fructose-induced dyslipidemia and hepatic oxidative …

RHH Ching, LOY Yeung, MY Iris, WH Sit, ETS Li - The Journal of nutrition, 2011 - Elsevier
This study examined the impact of maternal high-fructose intake and if metabolic control in
the offspring could benefit from supplementing bioactive food components such as bitter …

Exposure to maternal overnutrition and a high-fat diet during early postnatal development increases susceptibility to renal and metabolic injury later in life

CM Jackson, BT Alexander, L Roach… - American Journal …, 2012 - journals.physiology.org
Overnutrition during pre-and postnatal development both confer increased susceptibility to
renal and metabolic risks later in life; however, whether they have an additive effect on the …

Intergenerational metabolic syndrome and neuronal network hyperexcitability in autism

A Rivell, MP Mattson - Trends in neurosciences, 2019 - cell.com
We review evidence that suggests a role for excessive consumption of energy-dense foods,
particularly fructose, and consequent obesity and insulin resistance (metabolic syndrome) in …