Peptide drug development has made great progress in the last decade thanks to new
production, modification, and analytic technologies. Peptides have been produced and …

The ability to efficiently access cytosolic proteins is desired in both biological research and
medicine. However, targeting intracellular proteins is often challenging, because to reach …

Protein–protein interactions (PPIs) are involved at all levels of cellular organization, thus
making the development of PPI inhibitors extremely valuable. The identification of selective …

Self‐assembly is a powerful tool for constructing supramolecular materials for many
applications, ranging from energy harvesting to biomedicine. Among the methods to prepare …

Many proteins exert their biological activities through small exposed surface regions called
epitopes that are folded peptides of well‐defined three‐dimensional structures. Short …

Protein–protein interactions (PPIs) have emerged as important and challenging targets in
chemical biology and medicinal chemistry. The main difficulty encountered in the discovery …

Catechol, a major mussel‐inspired underwater adhesive moiety, has been used to develop
functional adhesive hydrogels for biomedical applications. However, oxidative catechol …

Mimics of α-helices on protein surfaces have emerged as powerful reagents for
antagonizing protein-protein interactions, which are difficult to target with small molecules …

This protocol presents a detailed description of the synthesis of N-methylated cyclic
peptides. N-methylation is a powerful technique to modulate the physicochemical properties …

Bioactive conformations of peptides can be stabilized by macrocyclization, resulting in
increased target affinity and activity. Such macrocyclic peptides proved useful as modulators …