Recent advances in small organic molecules as DNA intercalating agents: Synthesis, activity, and modeling

A Rescifina, C Zagni, MG Varrica, V Pistarà… - European journal of …, 2014 - Elsevier
The interaction of small molecules with DNA plays an essential role in many biological
processes. As DNA is often the target for majority of anticancer and antibiotic drugs, study …

Medicinal chemistry of acridine and its analogues

P Prasher, M Sharma - MedChemComm, 2018 - pubs.rsc.org
'Acridine'along with its functional analogue 'Acridone'is the most privileged pharmacophore
in medicinal chemistry with diverse applications ranging from DNA intercalators …

Drug–DNA intercalation: From discovery to the molecular mechanism

A Mukherjee, WD Sasikala - Advances in protein chemistry and structural …, 2013 - Elsevier
The ability of small molecules to perturb the natural structure and dynamics of nucleic acids
is intriguing and has potential applications in cancer therapeutics. Intercalation is a special …

New insights on the interaction of phenanthroline based ligands and metal complexes and polyoxometalates with duplex DNA and G-quadruplexes

Á Sánchez-González, NAG Bandeira… - Molecules, 2021 - mdpi.com
This work provides new insights from our team regarding advances in targeting canonical
and non-canonical nucleic acid structures. This modality of medical treatment is used as a …

DNA intercalation studies and antimicrobial activity of Ag@ ZrO2 core–shell nanoparticles in vitro

KI Dhanalekshmi, KS Meena - Materials Science and Engineering: C, 2016 - Elsevier
Ag@ ZrO 2 core–shell nanoparticles were prepared by one pot simultaneous reduction of
AgNO 3 and hydrolysis of zirconium (IV) isopropoxide. The formation of core–shell …

Anomalous water dynamics at surfaces and interfaces: synergistic effects of confinement and surface interactions

R Biswas, B Bagchi - Journal of Physics: Condensed Matter, 2017 - iopscience.iop.org
In nature, water is often found in contact with surfaces that are extended on the scale of
molecule size but small on a macroscopic scale. Examples include lipid bilayers and …

Chiral molecular imprinted sensor for highly selective determination of D-carnitine in enantiomers via dsDNA-assisted conformation immobilization

L Zhang, K Luo, D Li, Y Zhang, Y Zeng, J Li - Analytica Chimica Acta, 2020 - Elsevier
In this paper, a novel approach was established on the basis of a molecularly imprinted
technique with the aid of double-stranded deoxyribonucleic acid (dsDNA) embedded in a …

Concentration-dependent mode of binding of drug oxatomide with DNA: multi-spectroscopic, voltammetric and metadynamics simulation analysis

S Ponkarpagam, G Mahalakshmi… - Journal of …, 2022 - Taylor & Francis
The interaction between antihistaminic drug oxatomide (OXT) and calf-thymus DNA (CT-
DNA) has been investigated in a physiological buffer (pH 7.4) using UV–Vis, fluorescence …

Influence of conventional hydrogen bonds in the intercalation of phenanthroline derivatives with DNA: The important role of the sugar and phosphate backbone

Á Sánchez‐González, P Grenut… - Journal of Computational …, 2022 - Wiley Online Library
The influence of hydrogen bonds in model intercalated systems between guanine‐cytosine
and adenine‐thymine DNA base pairs (bps) was analyzed with the popular intercalator 1, 10 …

Computational Studies on the Binding Preferences of Molybdenum (II) Phenanthroline Complexes with Duplex DNA. The Important Role of the Ancillary Ligands

S Elleuchi, I Ortiz de Luzuriaga… - Inorganic …, 2020 - ACS Publications
The interaction of two isomers, equatorial (Eq) and axial (Ax), of the [Mo (η3-C3H5) Br (CO)
2 (phen)] metal complex with DNA was studied by using large-scaling density functional …