Objective: The protein phosphatase inhibitor-1 (I-1) is a highly specific and potent inhibitor of
type 1 phosphatases (PP1) that is active only in its protein kinase A (PKA)-phosphorylated …

Objective: Chronic pressure overload in spontaneously hypertensive rats (SHR) is
accompanied by heart hypertrophy and signs of heart failure. Since there is growing …

Sarcomeric protein abnormalities have been recognized for many years in heart failure due
to dilated cardiomyopathy (DCM). In contrast, virtually nothing is known about myofilament …

Type 1 protein phosphatase (PP1) is a negative regulator of cardiac function. However,
studies on the status and regulation of sarcoplasmic reticulum (SR)-associated PP1 activity …

The transcriptional activation mediated by cAMP-response element (CRE) and transcription
factors of the CRE-binding protein (CREB)/CRE modulator (CREM) family represents an …

Frequency-dependent acceleration of relaxation (FDAR) is an important intrinsic mechanism
that allows for diastolic filling of the ventricle at higher heart rates, yet its molecular …

Dephosphorylation of important myocardial proteins is regulated by protein phosphatase 2A
(PP2A), representing a heterotrimer that is comprised of catalytic, scaffolding, and regulatory …

Protein phosphatase (PP) type 2A is a multifunctional serine/threonine phosphatase that is
involved in cardiac excitation–contraction coupling. The PP2A core enzyme is a dimer …

Abstract Objective: Protein phosphatase 1 (PP1) has been implicated in the control of
cardiac function. Cardiac specific overexpression of the catalytic subunit, PP1c, results in …

As part of our ongoing studies on the potential pathophysiological role of serine/threonine
phosphatases (PP) in the mammalian heart, we have generated transgenic mice with …