Heart failure with preserved ejection fraction: heterogeneous syndrome, diverse preclinical models
Heart failure with preserved ejection fraction (HFpEF) represents one of the greatest
challenges facing cardiovascular medicine today. Despite being the most common form of …
challenges facing cardiovascular medicine today. Despite being the most common form of …
Small animal models of heart failure
C Riehle, J Bauersachs - Cardiovascular research, 2019 - academic.oup.com
Heart disease is a major cause of death worldwide with increasing prevalence, which urges
the development of new therapeutic strategies. Over the last few decades, numerous small …
the development of new therapeutic strategies. Over the last few decades, numerous small …
Murine models of heart failure with preserved ejection fraction: a “fishing expedition”
Heart failure with preserved ejection fraction (HFpEF) is characterized by signs and
symptoms of heart failure in the presence of a normal left ventricular ejection fraction …
symptoms of heart failure in the presence of a normal left ventricular ejection fraction …
Animal models of aging research: implications for human aging and age-related diseases
SJ Mitchell, M Scheibye-Knudsen… - Annu. Rev. Anim …, 2015 - annualreviews.org
Aging is characterized by an increasing morbidity and functional decline that eventually
results in the death of an organism. Aging is the largest risk factor for numerous human …
results in the death of an organism. Aging is the largest risk factor for numerous human …
The processes and mechanisms of cardiac and pulmonary fibrosis
Fibrosis is the formation of fibrous connective tissue in response to injury. It is characterized
by the accumulation of extracellular matrix components, particularly collagen, at the site of …
by the accumulation of extracellular matrix components, particularly collagen, at the site of …
The influence of dietary salt beyond blood pressure
Abstract Purpose of Review Excess sodium from dietary salt (NaCl) is linked to elevations in
blood pressure (BP). However, salt sensitivity of BP varies widely between individuals and …
blood pressure (BP). However, salt sensitivity of BP varies widely between individuals and …
ESC working group on cardiac cellular electrophysiology position paper: relevance, opportunities, and limitations of experimental models for cardiac electrophysiology …
Cardiac arrhythmias are a major cause of death and disability. A large number of
experimental cell and animal models have been developed to study arrhythmogenic …
experimental cell and animal models have been developed to study arrhythmogenic …
Reciprocal organ interactions during heart failure: a position paper from the ESC Working Group on Myocardial Function
Heart failure—either with reduced or preserved ejection fraction (HFrEF/HFpEF)—is a
clinical syndrome of multifactorial and gender-dependent aetiology, indicating the …
clinical syndrome of multifactorial and gender-dependent aetiology, indicating the …
Loss of endothelial endoglin promotes high-output heart failure through peripheral arteriovenous shunting driven by VEGF signaling
S Tual-Chalot, M Garcia-Collado… - Circulation …, 2020 - Am Heart Assoc
Rationale: ENG (endoglin) is a coreceptor for BMP (bone morphogenetic protein) 9/10 and
is strongly expressed in endothelial cells. Mutations in ENG lead to the inherited vascular …
is strongly expressed in endothelial cells. Mutations in ENG lead to the inherited vascular …
Metabolomic and transcriptomic signatures of chemogenetic heart failure
F Spyropoulos, A Sorrentino… - American Journal …, 2022 - journals.physiology.org
The failing heart is characterized by elevated levels of reactive oxygen species. We have
developed an animal model of heart failure induced by chemogenetic production of …
developed an animal model of heart failure induced by chemogenetic production of …