Bedrest as an experimental paradigm or as an in-patient stay for medical reasons has
negative consequences for cardiovascular health. The effects of severe inactivity parallel …

Performance fatigability is typically experienced as insufficient energy to complete daily
physical tasks, particularly with advancing age, often progressing toward dependency. Thus …

Gene expression in skeletal muscle of older individuals may reflect compensatory
adaptations in response to oxidative damage that preserve tissue integrity and maintain …

The age-related decline in muscle mitochondrial energetics contributes to the loss of
mobility in older adults. Women experience a higher prevalence of mobility impairment …

Background Phenotypic frailty syndrome identifies older adults at greater risk for adverse
health outcomes. Despite the critical role of mitochondria in maintaining cellular function …

Oxidative stress is considered a contributor to declining muscle function and mobility during
aging; however, the underlying molecular mechanisms remain poorly described. We …

The gradual deterioration of physiological systems with ageing makes it difficult to maintain
skeletal muscle mass (sarcopenia), at least partly due to the presence of 'anabolic …

Background Surgery for urological cancers is associated with high complication rates and
survivors commonly experience fatigue, reduced physical ability and quality of life. High …

Autophagy is essential for proteostasis, energetic balance, and cell defense and is a key
pathway in aging. Identifying associations between autophagy gene expression patterns in …

Background There is a lack of consensus about the operationalization of vitality, which is
one of the intrinsic capacity (IC) domains. In particular, no study has investigated whether …