Antioxidant peptides from monkfish swim bladders: ameliorating NAFLD in vitro by suppressing lipid accumulation and oxidative stress via regulating AMPK/Nrf2 …

MF Wu, QH Xi, Y Sheng, YM Wang, WY Wang, CF Chi… - Marine drugs, 2023 - mdpi.com
In this study, we investigate the ameliorating functions of QDYD (MSP2), ARW (MSP8),
DDGGK (MSP10), YPAGP (MSP13) and DPAGP (MSP18) from monkfish swim bladders on …

[HTML][HTML] Tissue-specific mechanisms of fat metabolism that focus on insulin actions

S Wu, J Tan, H Zhang, DX Hou, J He - Journal of Advanced Research, 2023 - Elsevier
Background The accumulation of ectopic fats is related to metabolic syndromes with insulin
resistance, which is considered as the first hit in obesity-related diseases. However …

Pharmacotherapy for non-alcoholic fatty liver disease: emerging targets and drug candidates

VA Prikhodko, NN Bezborodkina, SV Okovityi - Biomedicines, 2022 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD), or metabolic (dysfunction)-associated fatty liver
disease (MAFLD), is characterized by high global incidence and prevalence, a tight …

Faecal microbiota transplantation‐mediated jejunal microbiota changes halt high‐fat diet‐induced obesity in mice via retarding intestinal fat absorption

L Zhu, J Fu, X Xiao, F Wang, M Jin… - Microbial …, 2022 - Wiley Online Library
Summary Faecal Microbiota Transplantation (FMT) is considered as a promising technology
to fight against obesity. Wild boar has leanermuscle and less fat in comparison to the …

New insights in the control of fat homeostasis: the role of neurotensin

I Barchetta, MG Baroni, O Melander… - International Journal of …, 2022 - mdpi.com
Neurotensin (NT) is a small peptide with pleiotropic functions, exerting its primary actions by
controlling food intake and energy balance. The first evidence of an involvement of NT in …

[HTML][HTML] G protein-coupled receptors as potential targets for nonalcoholic fatty liver disease treatment

M Yang, CY Zhang - World Journal of Gastroenterology, 2021 - ncbi.nlm.nih.gov
Nonalcoholic fatty liver disease (NAFLD) is a broad-spectrum disease, ranging from simple
hepatic steatosis to nonalcoholic steatohepatitis, which can progress to cirrhosis and liver …

Uncarboxylated osteocalcin decreases SCD1 by activating AMPK to alleviate hepatocyte lipid accumulation

D Wang, M Zhang, J Xu, J Yang - Molecules, 2023 - mdpi.com
Uncarboxylated osteocalcin (GluOC), a small-molecule protein specifically synthesized and
secreted by osteoblasts, is important in the regulation of energy metabolism. In our previous …

Osteocalcin and non‐alcoholic fatty liver disease: lessons from two population‐based cohorts and animal models

M Xia, S Rong, X Zhu, H Yan, X Chang… - Journal of Bone and …, 2020 - academic.oup.com
Osteocalcin regulates energy metabolism in an active undercarboxylated/uncarboxylated
form. However, its role on the development of non‐alcoholic fatty liver disease (NAFLD) is …

The roles of osteocalcin in lipid metabolism in adipose tissue and liver

T Otani, A Mizokami, T Kawakubo-Yasukochi… - Advances in Biological …, 2020 - Elsevier
Bone provides skeletal support and functions as an endocrine organ by producing
osteocalcin, whose uncarboxylated form (GluOC) increases the metabolism of glucose and …

[HTML][HTML] Instrumentals behind embryo and cancer: a platform for prospective future in cancer research

KKM Sundaram, G Bupesh… - AIMS Molecular …, 2022 - aimspress.com
The cancer cells could be celled biomass without normal cellular regulation. They bypass
most of the signaling pathways leading to programmed cell division. On the other hand, the …