“Complimenting the complement”: mechanistic insights and opportunities for therapeutics in hepatocellular carcinoma

A Malik, U Thanekar, S Amarachintha, R Mourya… - Frontiers in …, 2021 - frontiersin.org
Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver and a
leading cause of death in the US and worldwide. HCC remains a global health problem and …

Monitoring immune checkpoint regulators as predictive biomarkers in hepatocellular carcinoma

R Shrestha, P Prithviraj, M Anaka, KR Bridle… - Frontiers in …, 2018 - frontiersin.org
The global burden of hepatocellular carcinoma (HCC), one of the frequent causes of cancer-
related deaths worldwide, is rapidly increasing partly due to the limited treatment options …

hsa_circRNA_103636: potential novel diagnostic and therapeutic biomarker in Major depressive disorder

X Cui, W Niu, L Kong, M He, K Jiang, S Chen… - Biomarkers in …, 2016 - Taylor & Francis
Aim This study aimed to determine whether circular RNA (circRNA) molecules in peripheral
blood mononuclear cells (PBMCs) could be used as novel non-invasive biomarkers for …

Components of the lectin pathway of complement in solid tumour cancers

M Cedzyński, AS Świerzko - Cancers, 2022 - mdpi.com
Simple Summary Cancer is a major cause of human deaths. The complement system is an
important branch of the innate immune response that can be activated via three distinct …

Development and validation of a three-gene prognostic signature for patients with hepatocellular carcinoma

B Li, W Feng, O Luo, T Xu, Y Cao, H Wu, D Yu… - Scientific reports, 2017 - nature.com
Hepatocellular carcinoma (HCC) is the leading cause of cancer-related death worldwide,
because recurrence often occurs in most HCC patients undergoing hepatectomy. It is …

BBCancer: an expression atlas of blood-based biomarkers in the early diagnosis of cancers

Z Zuo, H Hu, Q Xu, X Luo, D Peng, K Zhu… - Nucleic Acids …, 2020 - academic.oup.com
The early detection of cancer holds the key to combat and control the increasing global
burden of cancer morbidity and mortality. Blood-based screenings using circulating DNAs …

Serum glycoprotein markers in nonalcoholic steatohepatitis and hepatocellular carcinoma

P Ramachandran, G Xu, HH Huang… - Journal of Proteome …, 2022 - ACS Publications
Fatty liver disease progresses through stages of fat accumulation and inflammation to
nonalcoholic steatohepatitis (NASH), fibrosis and cirrhosis, and eventually hepatocellular …

Proteomic profiling of exosomes derived from plasma of HIV-infected alcohol drinkers and cigarette smokers

S Kodidela, Y Wang, BJ Patters, Y Gong… - Journal of Neuroimmune …, 2020 - Springer
Abuse of alcohol and tobacco could exacerbate HIV pathogenesis by transferring materials
through exosomes (small nanovesicles). Exosomes present a stable and accessible source …

Serum-derived exosomal proteins as potential candidate biomarkers for hepatocellular carcinoma

L Zhao, J Shi, L Chang, Y Wang, S Liu, Y Li… - ACS …, 2021 - ACS Publications
Hepatocellular carcinoma (HCC) is the most common form of hepatic malignancies. The
diagnosis of HCC remains challenging due to the low sensitivity and specificity of the …

TNF‑α‑mediated epithelial‑to‑mesenchymal transition regulates expression of immune checkpoint molecules in hepatocellular carcinoma

R Shrestha, KR Bridle… - Molecular …, 2020 - spandidos-publications.com
Hepatocellular carcinoma (HCC) is the fastest growing cause of cancer‑related deaths
globally. Epithelial‑to‑mesenchymal transition (EMT) is a cellular process that confers HCC …