Neuroplasticity, ie, the modifiability of the brain, is different in development and adulthood.
The first includes changes in:(i) neurogenesis and control of neuron number;(ii) neuronal …

The human brain is a complex network whose ensemble time evolution is directed by the
cumulative interactions of its cellular components, such as neurons and glia cells. Coupled …

Comprehensive electrophysiological characterizations of human induced pluripotent stem
cell (hiPSC)-derived neuronal networks are essential to determine to what extent these in …

Numerous studies suggest that biological neuronal networks self-organize toward a critical
state with stable recruitment dynamics. Individual neurons would then statistically activate …

The spatial distribution of neurons and activity-dependent neurite outgrowth shape long-
range interaction, recurrent local connectivity and the modularity in neuronal networks. We …

Techniques involving three-dimensional (3D) tissue structure reconstruction and analysis
provide a better understanding of changes in molecules and function. We have developed …

The idea of columns as an organizing cortical unit emerged from physiologic studies in the
sensory systems. Connectional studies and molecular markers pointed to widespread …

Multi-recording techniques show evidence that neurons coordinate their firing forming
ensembles and that brain networks are made by connections between ensembles. While …

The human brain is organized as a complex, hierarchical network. However, the structural
covariance patterns among brain regions and the underlying biological substrates of such …

Defining somatic gene mutations in brain tissue specimens has shed new light on how MCD
form and the mechanisms of epileptogenesis associated with MCD. Trials of mTOR …