One-carbon and polyamine metabolism as cancer therapy targets

A Islam, Z Shaukat, R Hussain, SL Gregory - Biomolecules, 2022 - mdpi.com
Cancer metabolic reprogramming is essential for maintaining cancer cell survival and rapid
replication. A common target of this metabolic reprogramming is one-carbon metabolism …

Risk factors for prostate cancer: An umbrella review of prospective observational studies and mendelian randomization analyses

H Cui, W Zhang, L Zhang, Y Qu, Z Xu, Z Tan… - Plos …, 2024 - journals.plos.org
Background The incidence of prostate cancer is increasing in older males globally. Age,
ethnicity, and family history are identified as the well-known risk factors for prostate cancer …

Relationship between plasma homocysteine and bone density, lean mass, muscle strength and physical function in 1480 middle-aged and older adults: data from …

J Kositsawat, S Vogrin, C French, M Gebauer… - Calcified Tissue …, 2023 - Springer
Hyperhomocysteinemia induces oxidative stress and chronic inflammation (both of which
are catabolic to bone and muscle); thus, we examined the association between …

Plasma One-Carbon Metabolism-Related Micronutrients and the Risk of Breast Cancer: Involvement of DNA Methylation

F Liu, H Zhou, Y Peng, Y Qiao, P Wang, C Si, X Wang… - Nutrients, 2023 - mdpi.com
Findings of epidemiologic studies focusing on the association between one-carbon
metabolism-related micronutrients and breast cancer risk, along with the involvement of …

[HTML][HTML] Serum Homocysteine Levels and All-Cause and Cause-Specific Mortality in Korean Adult Men: A Cohort Study

M Kim, S Shin, E Yoo, JH Kang, E Sung, CH Kim… - Nutrients, 2024 - mdpi.com
Background: Hyperhomocysteinemia can increase the risk of cardiovascular disease (CVD),
cancer, and neurological disorders; however, hypohomocysteinemia is generally not …

Mendelian randomization analysis does not reveal a causal influence of mental diseases on osteoporosis

F Tang, S Wang, H Zhao, D Xia, X Dong - Frontiers in Endocrinology, 2023 - frontiersin.org
Introduction Osteoporosis (OP) is primarily diagnosed through bone mineral density (BMD)
measurements, and it often leads to fracture. Observational studies suggest that several …

Confined active area and aggregation kinetic-based AuNPs@ PVP nanosensors for simultaneous colorimetric detection of cysteine and homocysteine as homologues …

HL Li, JL Liang, S Li, F Liu, JY Luo, ZJ Huang… - Microchimica Acta, 2025 - Springer
The detection of cysteine (Cys) and homocysteine (Hcy) in biological fluids has great
significance for early diagnosis, including Alzheimer's and Parkinson's disease. The …

A time-gated fluorescence strategy for discriminating and detecting three co-occurring biothiols in biological sample with an ion-engineered AuNCs sensor

X Chen, J Liang, Y Zhuo, Z Huang, J Luo, F Liu… - Microchemical …, 2025 - Elsevier
The concentration levels of biothiols, including cysteine (Cys), homocysteine (Hcy), and
glutathione (GSH), are closely associated with a variety of diseases. The reactions and …

Inflammatory bowel disease and cardiovascular disease: a two-sample Mendelian randomization analysis

K Wu, A Li, L Liu, T Shu, D Xia, X Sun - Frontiers in Cardiovascular …, 2022 - frontiersin.org
Background Although epidemiological studies have shown a positive relationship between
inflammatory bowel disease (IBD) and risk of cardiovascular disease (CVD) outcomes, a …

Causal association of sex hormone-binding globulin on gestational hypertension and pre-eclampsia: a two-sample Mendelian randomization study

Z Wu, J Chen, K Huang, Y Li, J Chen, B Lin… - The Journal of …, 2024 - Taylor & Francis
Objectives Pre-eclampsia (PE) and gestational hypertension (GH) are two different
categories of hypertensive disorders of pregnancy. Given earlier observational research, the …