Tetrazole hybrids with potential anticancer activity

J Zhang, S Wang, Y Ba, Z Xu - European journal of medicinal chemistry, 2019 - Elsevier
Cancer is one of the main causes of death throughout the world. The anticancer agents are
indispensable for the treatment of various cancers, but most of them currently on the market …

Tetrazoles for biomedicine

EA Popova, RE Trifonov… - Russian Chemical …, 2019 - iopscience.iop.org
The tetrazole ring is an important pharmacophore. It is a structural component in many
drugs, drug candidates (or lead compounds) and various biochemical reagents. This review …

A novel palladium (II) antitumor agent: Synthesis, characterization, DFT perspective, CT-DNA and BSA interaction studies via in-vitro and in-silico approaches

M Feizi-Dehnayebi, E Dehghanian… - … Acta Part A: Molecular …, 2021 - Elsevier
Since numerous people annually pass away due to cancer, research in this field is essential.
Thus a newly made and water like palladium (II) complex of formula [Pd (phen)(acac)] NO 3 …

Computational and experimental examinations of new antitumor palladium(II) complex: CT-DNA-/BSA-binding, in-silico prediction, DFT perspective, docking …

AS Dorafshan Tabatabai, E Dehghanian… - Journal of …, 2024 - Taylor & Francis
Since the design of metal complexes with better biological activities is important, herein a
new palladium (II) complex bearing en and acac (en and acac stand for ethylenediamine …

Half-sandwich iridium and ruthenium complexes: effective tracking in cells and anticancer studies

JJ Li, L Guo, Z Tian, S Zhang, Z Xu, Y Han, R Li… - Inorganic …, 2018 - ACS Publications
Half-sandwich metal-based anticancer complexes suffer from uncertain targets and
mechanisms of action. Herein we report the observation of the images of half-sandwich …

A comprehensive review on fused heterocyclic as DNA intercalators: Promising anticancer agents

V Sharma, M Gupta, P Kumar… - Current Pharmaceutical …, 2021 - ingentaconnect.com
Since the discovery of DNA intercalating agents (by Lerman, 1961), a growing number of
organic, inorganic, and metallic compounds have been developed to treat life-threatening …

Synthesis and characterization of Pd (II) antitumor complex, DFT calculation and DNA/BSA binding insight through the combined experimental and theoretical aspects

M Feizi-Dehnayebi, E Dehghanian… - Journal of Molecular …, 2021 - Elsevier
A novel palladium (II) complex,[Pd (bpy)(acac)] NO 3 (where bpy and acac are 2, 2′-
bipyridine and acetylacetonato), has been synthesized and fully characterized through 1 H …

Novel 4-quinoline-thiosemicarbazone derivatives: Synthesis, antiproliferative activity, in vitro and in silico biomacromolecule interaction studies and topoisomerase …

AG Ribeiro, SMV de Almeida, JF de Oliveira… - European Journal of …, 2019 - Elsevier
Abstract Twelve 2-(quinolin-4-ylmethylene) hydrazinecarbothioamide derivatives were
synthetized and their biological properties were investigated, among which, the ability to …

Spectroscopic and molecular modelling study of binding mechanism of bovine serum albumin with phosmet

AJ Rahman, D Sharma, D Kumar, M Pathak… - … Acta Part A: Molecular …, 2021 - Elsevier
Phosmet exerts its neurotoxicity by inhibiting acetylcholinesterase that catalyzes the
degradation of acetylcholine (a neurotransmitter). Serum proteins are known to influence the …

In vitro anticancer activity of parent and nano-encapsulated samarium (iii) complex towards antimicrobial activity studies and FS-DNA/BSA binding affinity

S Asadpour, Z Aramesh-Boroujeni, S Jahani - RSC advances, 2020 - pubs.rsc.org
Based on the potential anticancer properties of lanthanide complexes, the anticancer activity
of the Sm (III) complex containing a 2, 2′-bipyridine ligand (bpy) and its interaction with FS …