Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications

Q Tuo, S Zhang, P Lei - Medicinal research reviews, 2022 - Wiley Online Library
Ischemic stroke caused by arterial occlusion is the most common type of stroke, which is
among the most frequent causes of disability and death worldwide. Current treatment …

[HTML][HTML] The pathological role of ferroptosis in ischemia/reperfusion-related injury

HF Yan, QZ Tuo, QZ Yin, P Lei - Zoological research, 2020 - ncbi.nlm.nih.gov
Abstract Ischemia/reperfusion (I/R) is a pathological process that occurs in numerous organs
throughout the human body, and it is frequently associated with severe cellular damage and …

Thrombin induces ACSL4-dependent ferroptosis during cerebral ischemia/reperfusion

Q Tuo, Y Liu, Z Xiang, HF Yan, T Zou, Y Shu… - Signal transduction and …, 2022 - nature.com
Ischemic stroke represents a significant danger to human beings, especially the elderly.
Interventions are only available to remove the clot, and the mechanism of neuronal death …

Tau-mediated iron export prevents ferroptotic damage after ischemic stroke

QZ Tuo, P Lei, KA Jackman, XL Li, H Xiong… - Molecular …, 2017 - nature.com
Functional failure of tau contributes to age-dependent, iron-mediated neurotoxicity, and as
iron accumulates in ischemic stroke tissue, we hypothesized that tau failure may exaggerate …

2015 American Heart Association/American Stroke Association focused update of the 2013 guidelines for the early management of patients with acute ischemic stroke …

WJ Powers, CP Derdeyn, J Biller, CS Coffey, BL Hoh… - Stroke, 2015 - Am Heart Assoc
Purpose—The aim of this guideline is to provide a focused update of the current
recommendations for the endovascular treatment of acute ischemic stroke. When there is …

Mitochondrial ferritin attenuates cerebral ischaemia/reperfusion injury by inhibiting ferroptosis

P Wang, Y Cui, Q Ren, B Yan, Y Zhao, P Yu… - Cell death & …, 2021 - nature.com
Ischaemic stroke is becoming the most common cerebral disease in aging populations, but
the underlying molecular mechanism of the disease has not yet been fully elucidated …

Alteplase versus tenecteplase for thrombolysis after ischaemic stroke (ATTEST): a phase 2, randomised, open-label, blinded endpoint study

X Huang, BK Cheripelli, SM Lloyd, D Kalladka… - The Lancet …, 2015 - thelancet.com
Background In most countries, alteplase given within 4· 5 h of onset is the only approved
medical treatment for acute ischaemic stroke. The newer thrombolytic drug tenecteplase has …

[HTML][HTML] Intravenous administration of xenogenic adipose-derived mesenchymal stem cells (ADMSC) and ADMSC-derived exosomes markedly reduced brain infarct …

KH Chen, CH Chen, CG Wallace, CM Yuen, GS Kao… - Oncotarget, 2016 - ncbi.nlm.nih.gov
We tested the hypothesis that combined xenogenic (from mini-pig) adipose-derived
mesenchymal stem cell (ADMSC) and ADMSC-derived exosome therapy could reduce brain …

N6-methyladenosine demethylases Alkbh5/Fto regulate cerebral ischemia-reperfusion injury

K Xu, Y Mo, D Li, Q Yu, L Wang, F Lin… - … advances in chronic …, 2020 - journals.sagepub.com
Background: Although N6-methyladenosine (m6A) plays a very important role in different
biological processes, its function in the brain has not been fully explored. Thus, we …

Acceleration of tissue plasminogen activator-mediated thrombolysis by magnetically powered nanomotors

R Cheng, W Huang, L Huang, B Yang, L Mao, K Jin… - ACS …, 2014 - ACS Publications
Dose control and effectiveness promotion of tissue plasminogen activator (t-PA) for
thrombolysis are vitally important to alleviate serious side effects such as hemorrhage in …