The high-resolution structures of ribosomal subunits published in 2000 have revolutionized
the field of protein translation. They facilitated the determination and interpretation of …

Ribosomes, which are central to protein synthesis and convert transcribed mRNAs into
polypeptide chains, have been the focus of structural and biochemical studies for more than …

During protein synthesis, the ribosome controls the movement of tRNA and mRNA by means
of large-scale structural rearrangements. We describe structures of the intact bacterial …

One key question in protein biosynthesis is how the ribosome couples mRNA and tRNA
movements to prevent disruption of weak codon-anticodon interactions and loss of the …

SBDS protein (deficient in the inherited leukemia-predisposition disorder Shwachman-
Diamond syndrome) and the GTPase EFL1 (an EF-G homolog) activate nascent 60S …

Protein synthesis occurs on macromolecular machines, called ribosomes. Bacterial
ribosomes and the translational machinery represent one of the major targets for antibiotics …

A molecular motor is made of either a single macromolecule or a macromolecular complex.
Just like their macroscopic counterparts, molecular motors “transduce” input energy into …

The ribosome is one of the major targets in the cell for clinically used antibiotics. However,
the increase in multidrug resistant bacteria is rapidly reducing the effectiveness of our …

In bacteria, the intracellular concentration of several amino acids is controlled by
riboswitches,,,. One of the important regulatory circuits involves lysine-specific riboswitches …

The mitochondrial translation system originates from a bacterial ancestor but has
substantially diverged in the course of evolution. Here, we use single-particle cryo-electron …