Organoids are in vitro miniaturized and simplified model systems of organs that have gained
enormous interest for modelling tissue development and disease, and for personalized …

RNA-binding proteins (RBPs) are critical effectors of gene expression, and as such their
malfunction underlies the origin of many diseases. RBPs can recognize hundreds of …

Removal of introns from messenger RNA precursors (pre-mRNA splicing) is an essential
step for the expression of most eukaryotic genes. Alternative splicing enables the regulated …

The retinal pigment epithelium is a fundamental component of the retina that plays essential
roles in visual functions. Damage to the structure and function of the retinal pigment …

RNA-binding proteins (RBPs) regulate essentially every event in the lifetime of an RNA
molecule, from its production to its destruction. Whereas much has been learned about RNA …

Retinal development and maturation are orchestrated by a series of interacting signalling
networks that drive the morphogenetic transformation of the anterior developing brain …

Retinal diseases constitute a genetically and phenotypically diverse group of clinical
conditions leading to vision impairment or blindness with limited treatment options …

Inherited retinal diseases (IRDs) cause progressive loss of light-sensitive photoreceptors in
the eye and can lead to blindness. Gene-based therapies for IRDs have shown remarkable …

The primary cilium is a ubiquitous microtubule-based organelle that senses external
environment and modulates diverse signaling pathways in different cell types and tissues …

The Parkinson's disease-associated gene, LRRK2, is also associated with immune
disorders and infectious disease and is expressed in immune subsets. Here, we …