A comprehensive review and comparison of existing computational methods for intrinsically disordered protein and region prediction

Y Liu, X Wang, B Liu - Briefings in bioinformatics, 2019 - academic.oup.com
Intrinsically disordered proteins and regions are widely distributed in proteins, which are
associated with many biological processes and diseases. Accurate prediction of intrinsically …

Deep learning for mining protein data

Q Shi, W Chen, S Huang, Y Wang… - Briefings in …, 2021 - academic.oup.com
The recent emergence of deep learning to characterize complex patterns of protein big data
reveals its potential to address the classic challenges in the field of protein data mining …

iLearn: an integrated platform and meta-learner for feature engineering, machine-learning analysis and modeling of DNA, RNA and protein sequence data

Z Chen, P Zhao, F Li, TT Marquez-Lago… - Briefings in …, 2020 - academic.oup.com
With the explosive growth of biological sequences generated in the post-genomic era, one
of the most challenging problems in bioinformatics and computational biology is to …

Capturing non-local interactions by long short-term memory bidirectional recurrent neural networks for improving prediction of protein secondary structure, backbone …

R Heffernan, Y Yang, K Paliwal, Y Zhou - Bioinformatics, 2017 - academic.oup.com
Motivation The accuracy of predicting protein local and global structural properties such as
secondary structure and solvent accessible surface area has been stagnant for many years …

Improving protein disorder prediction by deep bidirectional long short-term memory recurrent neural networks

J Hanson, Y Yang, K Paliwal, Y Zhou - Bioinformatics, 2017 - academic.oup.com
Motivation Capturing long-range interactions between structural but not sequence neighbors
of proteins is a long-standing challenging problem in bioinformatics. Recently, long short …

Sixty-five years of the long march in protein secondary structure prediction: the final stretch?

Y Yang, J Gao, J Wang, R Heffernan… - Briefings in …, 2018 - academic.oup.com
Protein secondary structure prediction began in 1951 when Pauling and Corey predicted
helical and sheet conformations for protein polypeptide backbone even before the first …

Improving prediction of protein secondary structure, backbone angles, solvent accessibility and contact numbers by using predicted contact maps and an ensemble of …

J Hanson, K Paliwal, T Litfin, Y Yang, Y Zhou - Bioinformatics, 2019 - academic.oup.com
Motivation Sequence-based prediction of one dimensional structural properties of proteins
has been a long-standing subproblem of protein structure prediction. Recently, prediction …

SPOT-Disorder2: improved protein intrinsic disorder prediction by ensembled deep learning

J Hanson, KK Paliwal, T Litfin… - Genomics, Proteomics …, 2019 - academic.oup.com
Intrinsically disordered or unstructured proteins (or regions in proteins) have been found to
be important in a wide range of biological functions and implicated in many diseases. Due to …

The structural context of posttranslational modifications at a proteome-wide scale

I Bludau, S Willems, WF Zeng, MT Strauss… - PLoS …, 2022 - journals.plos.org
The recent revolution in computational protein structure prediction provides folding models
for entire proteomes, which can now be integrated with large-scale experimental data. Mass …

Exploring spatial-frequency-sequential relationships for motor imagery classification with recurrent neural network

T Luo, C Zhou, F Chao - BMC bioinformatics, 2018 - Springer
Background Conventional methods of motor imagery brain computer interfaces (MI-BCIs)
suffer from the limited number of samples and simplified features, so as to produce poor …