Metabolic pathways and redox reactions are at the core of life. In the past decade (s),
numerous discoveries have shed light on how metabolic pathways determine the cellular …

Amino acid metabolism is a critical regulator of the immune response, and its modulating
becomes a promising approach in various forms of immunotherapy. Insufficient …

The discovery of interleukin-2 (IL-2) changed the molecular understanding of how the
immune system is controlled. IL-2 is a pleiotropic cytokine, and dissecting the signaling …

The remarkable success of immune checkpoint inhibitors demonstrates the potential of
tumour-specific CD8+ T cells to prevent and treat cancer. Although the number of lives …

Metabolism drives function, on both an organismal and a cellular level. In T cell biology,
metabolic remodeling is intrinsically linked to cellular development, activation, function …

Exercise has a wide range of systemic effects. In animal models, repeated exertion reduces
malignant tumor progression, and clinically, exercise can improve outcome for cancer …

Recent advances in the field of immunometabolism support the concept that fundamental
processes in T cell biology, such as TCR-mediated activation and T helper lineage …

T cell activation, proliferation, and differentiation into effector and memory states involve
massive remodeling of T cell size and molecular content and create a massive increase in …

Failure to make adaptive immune responses is a hallmark of aging. Reduced B cell function
leads to poor vaccination efficacy and a high prevalence of infections in the elderly. Here we …

T cells represent a critical effector of cell-mediated immunity. Activated T cells engage in
metabolic reprogramming during effector differentiation to accommodate dynamic changes …