Recent genetic and genomic advancements have elucidated the complex etiology of
idiopathic pulmonary fibrosis (IPF) and other progressive fibrotic interstitial lung diseases …

Rationale: Methylation integrates factors present at birth and modifiable across the lifespan
that can influence pulmonary function. Studies are limited in scope and replication …

Background Soluble receptor for advanced glycation end products (sRAGE) is a proposed
emphysema and airflow obstruction biomarker; however, previous publications have shown …

Whether smoking-associated DNA methylation has a causal effect on lung function has not
been thoroughly evaluated. We first investigated the causal effects of 474 smoking …

Muscle bulk in adult healthy humans is highly variable even after height, age, and sex are
accounted for. Low muscle mass, due to fewer and/or smaller constituent muscle fibers …

Acylcholines are comprised of an acyl chain esterified to a choline moiety; acetylcholine is
the best-characterized member of this class, functioning as a neurotransmitter in the central …

Rationale: The ability of peripheral blood biomarkers to assess chronic obstructive
pulmonary disease (COPD) risk and progression is unknown. Genetics and gene …

Background Some people have characteristics of both asthma and COPD (asthma-COPD
overlap), and evidence suggests they experience worse outcomes than those with either …

Rationale: Chronic obstructive pulmonary disease (COPD) has been associated with
numerous genetic variants, yet the extent to which its genetic risk is mediated by variation in …

While polygenic risk scores (PRSs) enable early identification of genetic risk for chronic
obstructive pulmonary disease (COPD), predictive performance is limited when the …