Copper toxicity links to pathogenesis of Alzheimer's disease and therapeutics approaches

HW Ejaz, W Wang, M Lang - International Journal of Molecular Sciences, 2020 - mdpi.com
Alzheimer's disease (AD) is an irreversible, age-related progressive neurological disorder,
and the most common type of dementia in aged people. Neuropathological lesions of AD …

A closer look at amyloid ligands, and what they tell us about protein aggregates

TS Chisholm, CA Hunter - Chemical Society Reviews, 2024 - pubs.rsc.org
The accumulation of amyloid fibrils is characteristic of neurodegenerative diseases such as
Alzheimer's disease (AD) and Parkinson's disease. Detecting these fibrils with fluorescent or …

An Activatable NIR‐II Fluorescent Reporter for In Vivo Imaging of Amyloid‐β Plaques

J Miao, M Miao, Y Jiang, M Zhao, Q Li… - Angewandte Chemie …, 2023 - Wiley Online Library
Fluorescence imaging in the second near‐infrared (NIR‐II) window holds great promise for
in vivo visualization of amyloid‐β (Aβ) pathology, which can facilitate characterization and …

Dual aggregations of a near-infrared aggregation-induced emission luminogen for enhanced imaging of Alzheimer's disease

L Xu, H Gao, W Zhan, Y Deng, X Liu… - Journal of the …, 2023 - ACS Publications
Aggregation-induced emission (AIE) enables “Turn-On” imaging generally through single
aggregation of the AIE luminogen (AIEgen). Dual aggregrations of the AIEgen might further …

Precise deciphering of brain vasculatures and microscopic tumors with dual NIR‐II fluorescence and photoacoustic imaging

B Guo, Z Feng, D Hu, S Xu, E Middha, Y Pan… - Advanced …, 2019 - Wiley Online Library
Diagnostics of cerebrovascular structures and microscopic tumors with intact blood–brain
barrier (BBB) significantly contributes to timely treatment of patients bearing neurological …

Anticancer potency of copper (II) complexes of thiosemicarbazones

NK Singh, AA Kumbhar, YR Pokharel… - Journal of Inorganic …, 2020 - Elsevier
Being a structural and catalytic cofactor in a number of biological pathways, copper
accumulates in tumors owing to selective permeability of the cancer cell membranes …

Amphiphilic distyrylbenzene derivatives as potential therapeutic and imaging agents for soluble and insoluble amyloid β aggregates in Alzheimer's disease

L Sun, HJ Cho, S Sen, AS Arango… - Journal of the …, 2021 - ACS Publications
Alzheimer's Disease (AD) is the most common neurodegenerative disease, and efficient
therapeutic and early diagnostic agents for AD are still lacking. Herein, we report the …

Cu and Zn interactions with Aβ peptides: consequence of coordination on aggregation and formation of neurotoxic soluble Aβ oligomers

M Rana, AK Sharma - Metallomics, 2019 - academic.oup.com
The coordination chemistry of transition metal ions (Fe, Cu, Zn) with the amyloid-β (Aβ)
peptides has attracted a lot of attention in recent years due to its repercussions in …

Turn-on chemiluminescence probes and dual-amplification of signal for detection of amyloid beta species in vivo

J Yang, W Yin, R Van, K Yin, P Wang, C Zheng… - Nature …, 2020 - nature.com
Turn-on fluorescence imaging is routinely studied; however, turn-on chemiluminescence
has been rarely explored for in vivo imaging. Herein, we report the design and validation of …

Metal complexes that bind to the amyloid-β peptide of relevance to Alzheimer's disease

LMF Gomes, JC Bataglioli, T Storr - Coordination Chemistry Reviews, 2020 - Elsevier
Alzheimer's disease (AD) is the most common form of dementia, and is a multi-faceted
disease that is characterized by oxidative stress, metal-ion dysregulation, and the formation …