[HTML][HTML] The contribution of dormant origins to genome stability: from cell biology to human genetics
RC Alver, GS Chadha, JJ Blow - DNA repair, 2014 - Elsevier
The ability of a eukaryotic cell to precisely and accurately replicate its DNA is crucial to
maintain genome stability. Here we describe our current understanding of the process by …
maintain genome stability. Here we describe our current understanding of the process by …
Developmental Control of the Cell Cycle: Insights from Caenorhabditis elegans
ET Kipreos, S van den Heuvel - Genetics, 2019 - academic.oup.com
During animal development, a single fertilized egg forms a complete organism with tens to
trillions of cells that encompass a large variety of cell types. Cell cycle regulation is therefore …
trillions of cells that encompass a large variety of cell types. Cell cycle regulation is therefore …
Mitotic CDK promotes replisome disassembly, fork breakage, and complex DNA rearrangements
DNA replication errors generate complex chromosomal rearrangements and thereby
contribute to tumorigenesis and other human diseases. One mechanism that triggers these …
contribute to tumorigenesis and other human diseases. One mechanism that triggers these …
MCM2-7 loading-dependent ORC release ensures genome-wide origin licensing
Origin recognition complex (ORC)-dependent loading of the replicative helicase MCM2-7
onto replication origins in G1-phase forms the basis of replication fork establishment in S …
onto replication origins in G1-phase forms the basis of replication fork establishment in S …
[HTML][HTML] Isolation, profiling, and tracking of extracellular vesicle cargo in Caenorhabditis elegans
Extracellular vesicles (EVs) may mediate intercellular communication by carrying protein
and RNA cargo. The composition, biology, and roles of EVs in physiology and pathology …
and RNA cargo. The composition, biology, and roles of EVs in physiology and pathology …
A new class of disordered elements controls DNA replication through initiator self-assembly
The initiation of DNA replication in metazoans occurs at thousands of chromosomal sites
known as origins. At each origin, the Origin Recognition Complex (ORC), Cdc6, and Cdt1 co …
known as origins. At each origin, the Origin Recognition Complex (ORC), Cdc6, and Cdt1 co …
TRAIP drives replisome disassembly and mitotic DNA repair synthesis at sites of incomplete DNA replication
R Sonneville, R Bhowmick, S Hoffmann, N Mailand… - Elife, 2019 - elifesciences.org
The faithful segregation of eukaryotic chromosomes in mitosis requires that the genome be
duplicated completely prior to anaphase. However, cells with large genomes sometimes fail …
duplicated completely prior to anaphase. However, cells with large genomes sometimes fail …
CUL-2LRR-1 and UBXN-3 drive replisome disassembly during DNA replication termination and mitosis
R Sonneville, SP Moreno, A Knebel, C Johnson… - Nature cell …, 2017 - nature.com
Replisome disassembly is the final step of DNA replication in eukaryotes, involving the
ubiquitylation and CDC48-dependent dissolution of the CMG helicase (CDC45–MCM …
ubiquitylation and CDC48-dependent dissolution of the CMG helicase (CDC45–MCM …
Dynamic loading and redistribution of the Mcm2‐7 helicase complex through the cell cycle
SK Powell, HK MacAlpine, JA Prinz, Y Li… - The EMBO …, 2015 - embopress.org
Eukaryotic replication origins are defined by the ORC‐dependent loading of the Mcm2‐7
helicase complex onto chromatin in G1. Paradoxically, there is a vast excess of Mcm2‐7 …
helicase complex onto chromatin in G1. Paradoxically, there is a vast excess of Mcm2‐7 …
The capacity of origins to load MCM establishes replication timing patterns
L Dukaj, N Rhind - PLoS Genetics, 2021 - journals.plos.org
Loading of the MCM replicative helicase at origins of replication is a highly regulated
process that precedes DNA replication in all eukaryotes. The stoichiometry of MCM loaded …
process that precedes DNA replication in all eukaryotes. The stoichiometry of MCM loaded …