Insights into the chemistry and therapeutic potential of acrylonitrile derivatives

O Unsal Tan, M Zengin - Archiv der Pharmazie, 2022 - Wiley Online Library
Acrylonitrile is a fascinating scaffold widely found in many natural products, drugs, and drug
candidates with various biological activities. Several drug molecules such as entacapone …

Sulfonic acid functionalized metal–organic framework (S-IRMOF-3): a novel catalyst for sustainable approach towards the synthesis of acrylonitriles

RA Rather, ZN Siddiqui - RSC advances, 2019 - pubs.rsc.org
A sulfonic acid functionalized metal–organic framework (S-IRMOF-3) has been synthesized
by dropwise addition of chlorosulfonic acid (0.5 mL) in IRMOF-3 (1 g) containing 20 mL of …

An SiO 2/ZnBr 2 mediated expeditious approach to 3-methyl-1-phenyl-1 H-pyrazol-5 (4 H)-one derivatives in water under microwave irradiation

M Parveen, S Azaz, AM Malla, F Ahmad, M Ahmad… - RSC Advances, 2016 - pubs.rsc.org
A new one-pot three-component green approach has been developed for the synthesis of a
series of pyrazolone derivatives 2 (a–s) from differently substituted aromatic aldehydes …

Synthesis and evaluation of bile acid amides of -cyanostilbenes as anticancer agents

DS Agarwal, RP Singh, K Lohitesh, PN Jha… - Molecular Diversity, 2018 - Springer
A series of amino-substituted α α-cyanostilbene derivatives and their bile acid (cholic and
deoxycholic acid) amides were designed and synthesized. A comparative study on the …

Synthesis and in silico analysis of the quantitative structure–activity relationship of heteroaryl–acrylonitriles as AChE inhibitors

P De-la-Torre, AV Treuer, M Gutierrez, H Poblete… - Journal of the Taiwan …, 2016 - Elsevier
Alzheimer disease (AD) is a neurodegenerative disorder that causes damages in brain due
to factors such as oxidative stress, low-levels of the neurotransmitter acetylcholine, β …

Microwave-assisted expeditious approach towards benzimidazole acrylonitrile derivatives exploring a new silica supported SBPTS catalyst

F Ahmad, M Parveen - New Journal of Chemistry, 2018 - pubs.rsc.org
The present study reports a simple, highly efficient and green approach for the synthesis of a
series of benzimidazole-acrylonitrile derivatives 3 (a–l). The synthetic methodology involves …

[Et 3 NH][HSO 4]-catalyzed eco-friendly and expeditious synthesis of thiazolidine and oxazolidine derivatives

AM Malla, M Parveen, F Ahmad, S Azaz, M Alam - RSC Advances, 2015 - pubs.rsc.org
The present study reports a facile and green approach for the synthesis of thiazolidine/
oxazolidine derivatives 4 (a–u) in excellent yields (92–98%) with high purity. The protocol …

Silica Bonded N-(Propylcarbamoyl)sulfamic acid (SBPCSA) Mediated Expeditious Approach to C–C Bond Formation: An Innovative Pathway for Acrylonitrile …

M Parveen, S Azaz, F Ahmad, AM Malla, M Alam - Catalysis Letters, 2016 - Springer
A new silica bonded N-(propylcarbamoyl) sulfamic acid (SBPCSA) catalyst has been
prepared for the highly efficient synthesis of a series of acrylonitrile derivatives via solvent …

Blue Glow Sticks: Cinnamic acids and arylacrylonitriles with liquid-crystalline properties and highly fluorescent

A Tavares, RO Costa, CSB Weber, T Cazati… - Journal of the Brazilian …, 2021 - SciELO Brasil
Five new π-conjugated chromophores derived from acrylic acid and acrylonitrile were
synthesized and their thermal and photophysical behaviors were analyzed. They were …

Synthesis and characterization of benzotriazolyl acrylonitrile analogs-based donor-acceptor molecules: Optical properties, in vitro cytotoxicity, and cellular imaging

E Hernandez-Fernandez, AS Ortega-Villarreal… - Dyes and …, 2021 - Elsevier
A series of eight new (E)-benzotriazolyl acrylonitrile derivatives were synthesized under
reflux conditions via Knoevenagel condensation between acetonitrile analogs and a short …