Covering: up to April 2014 The development of drugs with broad-spectrum antiviral activities
is a long pursued goal in drug discovery. It has been shown that blocking co-opted host …

Hepatitis C virus (HCV) envelope glycoprotein heterodimer, E1E2, plays an essential role in
virus entry and assembly. Furthermore, due to their exposure at the surface of the virion …

Inter-tumor heterogeneity is a result of genomic, transcriptional, translational, and post-
translational molecular features. To investigate the roles of protein glycosylation in the …

Genetic defects in MOGS, the gene encoding mannosyl-oligosaccharide glucosidase (the
first enzyme in the processing pathway of N-linked oligosaccharide), cause the rare …

The recent COVID-19 crisis has highlighted the importance of RNA-based viruses. The most
prominent members of this group are SARS-CoV-2 (coronavirus), HIV (human …

Protein glycosylation is an important epigenetic modifying process affecting expression,
localization, and function of numerous proteins required for normal immune function …

Endoplasmic reticulum (ER)-resident α-glucosidases I and II sequentially trim the three
terminal glucose moieties on N-linked glycans attached to nascent glycoproteins. These …

The ongoing COVID-19 pandemic, caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), is a major threat to global health. Vaccines are ideal solutions …

It has long been thought that iminosugar antiviral activity is a function of inhibition of
endoplasmic reticulum-resident α-glucosidases, and on this basis, many iminosugars have …

Zika Virus (ZIKV) infection is a global threat. Other than the congenital neurological
disorders it causes, ZIKV infection has been reported to induce cardiac complications …