Curved membranes are key features of intracellular organelles, and their generation
involves dynamic protein complexes. Here we describe the fundamental mechanisms such …

Cellular membranes self-assemble from and interact with various molecular species. Each
molecule locally shapes the lipid bilayer, the soft elastic core of cellular membranes. The …

The structure-function paradigm has guided investigations into the molecules involved in
cellular signalling for decades. The peripheries of this paradigm, however, start to unravel …

Cellular membranes are highly dynamic in shape. They can rapidly and precisely regulate
their shape to perform various cellular functions. The protein's ability to sense membrane …

Clathrin-mediated endocytosis is pivotal to signal transduction pathways between the
extracellular environment and the intracellular space. Evidence from live-cell imaging and …

Intrinsically disordered regions (IDRs) play a pivotal role in organellar remodeling. They
transduce signals across membranes, scaffold signaling complexes, and mediate vesicular …

The ability of proteins to assemble at sites of high membrane curvature is essential to
diverse membrane remodeling processes, including clathrin-mediated endocytosis. Multiple …

Excessive reactive oxygen species (ROS) in cellular environments leads to oxidative stress,
which underlies numerous diseases, including inflammatory diseases, neurodegenerative …

Curvature-inducing proteins containing a bin/amphiphysin/Rvs domain often have
intrinsically disordered domains. Recent experiments have shown that these disordered …

This review examines the relationships between membrane chemistry, curvature-sensing
proteins, and cellular morphogenesis. Curvature-sensing proteins are often orders of …