RAS and MYC rank amongst the most commonly altered oncogenes in cancer, with RAS
being the most frequently mutated and MYC the most amplified. The cooperative interplay …

KRAS is one of the most mutated genes, driving alternations in metabolic pathways that
include enhanced nutrient uptaking, increased glycolysis, elevated glutaminolysis, and …

Colorectal cancer (CRC) is a heterogeneous disease with a myriad of alterations at the
cellular and molecular levels. Kristen rat sarcoma (KRAS) mutations occur in up to 40% of …

Simple Summary Pancreatic ductal adenocarcinoma is one of the deadliest malignancies in
humans. Despite advances in systemic therapy, prognosis still remains poor. However …

Dysregulation of the flow of information from genomic DNA to RNA to protein occurs within
all cancer types. In this review, we described the current state of understanding of how RNA …

KRAS belongs to a family of small GTPases that act as binary switches upstream of several
signalling cascades, controlling proliferation and survival of cells. Mutations in KRAS drive …

KRAS, the most frequently mutated oncogene in human cancer, produces two isoforms,
KRAS4a and KRAS4b, through alternative splicing. These isoforms differ in exon 4, which …

Abstract KRAS, HRAS and NRAS proto-oncogenes belong to a family of 40 highly
homologous genes, which in turn are a subset of a superfamily of> 160 genes encoding …

Although specific proteins have been identified that regulate the membrane association and
facilitate intracellular transport of prenylated Rho-and Rab-family proteins, it is not known …

RNA splicing is the process of forming mature mRNA, which is an essential phase
necessary for gene expression and controls many aspects of cell proliferation, survival, and …