Cystic Fibrosis (CF) is a genetic disorder that arises due to mutations in the Cystic Fibrosis
Transmembrane Conductance Regulator gene, which encodes for a protein responsible for …

The role of Cl–as an intracellular signaling ion has been increasingly recognized in recent
years. One of the currently best described roles of Cl–in signaling is the modulation of the W …

Rationale: Cystic fibrosis (CF) is caused by mutations in the CFTR (CF transmembrane
conductance regulator) gene and is characterized by sustained inflammation. ATP triggers …

The specific role of the chloride anion (Cl−) as a signalling effector or second messenger
has been increasingly recognized in recent years. It could represent a key factor in the …

Cl− is the major extracellular (Cl− out) and intracellular (Cl− in) anion whose concentration
is actively regulated by multiple transporters. These transporters generate Cl− gradients …

Innate immune cells, epithelial cells, and many other cell types are capable of detecting
infection or tissue injury, thus mounting regulated immune response. Inflammasomes are …

Beyond its role as the “queen of electrolytes”, chloride can also serve as an allosteric
regulator or even a signaling ion. To illuminate this essential anion across such a spectrum …

Abstracts Airway epithelial cells harbor the capacity of active Cl− transepithelial transport
and play critical roles in modulating innate immunity. However, whether intracellular Cl …

Chloride (Cl-) homeostasis is an essential process involved in neuronal signalling and cell
survival. Inadequate regulation of intracellular Cl-interferes with synaptic signalling and is …

Chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF) are lethal pulmonary
diseases. Cigarette consumption is the main cause for development of COPD, while CF is …