To a large extent, cancer conforms to evolutionary rules defined by the rates at which clones
mutate, adapt and grow. Next-generation sequencing has provided a snapshot of the …

Aneuploidy, an abnormal chromosome composition, is a major contributor to cancer
development and progression and an important determinant of cancer therapeutic …

Genome editing has therapeutic potential for treating genetic diseases and cancer.
However, the currently most practicable approaches rely on the generation of DNA double …

Chromosomal instability in cancer consists of dynamic changes to the number and structure
of chromosomes,. The resulting diversity in somatic copy number alterations (SCNAs) may …

Chromosome segregation errors during cell divisions generate aneuploidies and
micronuclei, which can undergo extensive chromosomal rearrangements such as …

APOBEC3 enzymes are cytosine deaminases implicated in cancer. Precisely when
APOBEC3 expression is induced during cancer development remains to be defined. Here …

Aneuploidy, a genomic alternation characterized by deviations in the copy number of
chromosomes, affects organisms from early development through to aging. Although it is a …

The prevalence and nature of somatic copy number alterations (CNAs) in breast epithelium
and their role in tumor initiation and evolution remain poorly understood. Using single-cell …

Breast cancer is the most common cancer among women globally. Genomic instability (GI)
refers to the increased tendency to accrue genomic alterations. It drives heterogeneity and is …

Complex genome rearrangements can be generated by the catastrophic pulverization of
missegregated chromosomes trapped within micronuclei through a process known as …