[HTML][HTML] A Splice Form of VEGF, a Potential Anti-Angiogenetic Form of Head and Neck Squamous Cell Cancer Inhibition

CS Dumitru, M Raica - International Journal of Molecular Sciences, 2024 - mdpi.com
Angiogenesis, primarily mediated by vascular endothelial growth factor (VEGF), is a
fundamental step in the progression and metastasis of head and neck squamous cell …

Soluble FLT-1 in angiogenesis: pathophysiological roles and therapeutic implications

LEI Wazan, A Widhibrata, GS Liu - Angiogenesis, 2024 - Springer
Fine-tuning angiogenesis, the development of new blood vessels, is essential for
maintaining a healthy circulatory and lymphatic system. The small glycoprotein vascular …

[HTML][HTML] Dihydroartemisinin inhibited vasculogenic mimicry in gastric cancer through the FGF2/FGFR1 signaling pathway

H Wang, Q Ding, C Huang, G Liu, X Zhao, Z Cheng… - Phytomedicine, 2024 - Elsevier
Vasculogenic mimicry (VM) is a novel model for supplying blood to multiple tumors,
including gastric cancer (GC), and is a potential target for its treatment. Dihydroartemisinin …

VEGF-A ameliorates ischemia hippocampal neural injury via regulating autophagy and Akt/CREB signaling in a rat model of chronic cerebral hypoperfusion

K Kang, DP Wang, QL Lv, F Chen - Journal of Stroke and Cerebrovascular …, 2023 - Elsevier
Objective Chronic cerebral hypoperfusion (CCH) can cause a series of pathophysiological
processes, including neuronal autophagy and apoptosis. VEGF-A has been reported to …

[HTML][HTML] Fibroblast growth factor 2 (FGF2) activates vascular endothelial growth factor (VEGF) signaling in gastrointestinal stromal tumors (GIST): an autocrine …

S Boichuk, P Dunaev, A Galembikova, E Valeeva - Cancers, 2024 - mdpi.com
Simple Summary The FGF/FGFR-mediated pathway coordinates the activity of
VEGF/VEGFR signaling in IM-resistant GISTs. Mechanistically, FGF2 triggers the activation …

Melatonin attenuates diabetic cardiomyopathy by increasing autophagy of cardiomyocytes via regulation of VEGF-B/GRP78/PERK signaling pathway

S Zhang, W Tian, X Duan, Q Zhang, L Cao… - Cardiovascular …, 2024 - Springer
Aims Diabetic cardiomyopathy (DCM) is a major cause of mortality in patients with diabetes,
and the potential strategies for treating DCM are insufficient. Melatonin (Mel) has been …

CORUM in 2024: protein complexes as drug targets

R Steinkamp, G Tsitsiridis, B Brauner… - Nucleic Acids …, 2025 - academic.oup.com
Abstract CORUM (https://mips. helmholtz-muenchen. de/corum/) is a public database that
offers comprehensive information about mammalian protein complexes, including their …

[HTML][HTML] Reduction reactions dominate the interactions between Mg alloys and cells: Understanding the mechanisms

J Kim, JL Gilbert, WW Lv, P Du, H Pan - Bioactive Materials, 2025 - Elsevier
Magnesium (Mg) alloys are popular biodegradable metals studied for orthopedic and
cardiovascular applications, mainly because Mg ions are essential trace elements known to …

Endothelial Pim3 kinase protects the vascular barrier during lung metastasis

NM Santio, K Ganesh, PP Kaipainen, A Halme… - Nature …, 2024 - nature.com
Endothelial cells (ECs) form a tissue-specific barrier for disseminating cancer cells in distant
organs. However, the molecular regulation of the ECs in the metastatic niche remains …

Proteome-wide mendelian randomization identifies causal plasma proteins in interstitial lung disease

K Yu, W Li, W Long, Y Li, Y Li, H Liao, J Liu - Scientific Reports, 2025 - nature.com
Interstitial lung disease (ILD) has shown limited treatment advancements, with minimal
exploration of circulating protein biomarkers causally linked to ILD and its subtypes beyond …