The three-dimensional in vitro cell culture models in the study of oral cancer immune microenvironment
E Dalir Abdolahinia, X Han - Cancers, 2023 - mdpi.com
Simple Summary The extensive array of applications in 3D culture models closely mimics
the precise physiological conditions of in vivo settings, enabling the investigation of …
the precise physiological conditions of in vivo settings, enabling the investigation of …
Targeting PI3K/AKT/mTOR signaling pathway as a radiosensitization in head and neck squamous cell carcinomas
YC Su, WC Lee, CC Wang, SA Yeh, WH Chen… - International Journal of …, 2022 - mdpi.com
Globally, there are over half a million new patients with head and neck squamous cell
carcinomas (HNSCC) every year. The current therapeutic approaches to HNSCC are …
carcinomas (HNSCC) every year. The current therapeutic approaches to HNSCC are …
Mapping the Potential of Microfluidics in Early Diagnosis and Personalized Treatment of Head and Neck Cancers
Simple Summary Head and neck cancers (HNCs) are a group of cancers that affect parts
like the mouth, throat, and glands in the neck. These cancers are quite complex and can be …
like the mouth, throat, and glands in the neck. These cancers are quite complex and can be …
Identity matters: cancer stem cells and tumour plasticity in head and neck squamous cell carcinoma
Head and neck squamous cell carcinoma (HNSCC) represents frequent yet aggressive
tumours that encompass complex ecosystems of stromal and neoplastic components …
tumours that encompass complex ecosystems of stromal and neoplastic components …
Novel human lymph node-derived matrix supports the adhesion of metastatic oral carcinoma cells
E Naakka, W Wahbi, R Tiikkaja, K Juurikka, T Sandvik… - BMC cancer, 2023 - Springer
Background 3D culture is increasingly used in cancer research, as it allows the growth of
cells in an environment that mimics in vivo conditions. Metastases are the primary cause of …
cells in an environment that mimics in vivo conditions. Metastases are the primary cause of …
In vitro models for head and neck cancer: Current status and future perspective
The 5-year overall survival rate remains approximately 50% for head and neck (H&N)
cancer patients, even though new cancer drugs have been approved for clinical use since …
cancer patients, even though new cancer drugs have been approved for clinical use since …
The critical effects of matrices on cultured carcinoma cells: human tumor-derived matrix promotes cell invasive properties
W Wahbi, E Naakka, K Tuomainen… - Experimental cell …, 2020 - Elsevier
The interaction between squamous cell carcinoma (SCC) cells and the tumor
microenvironment (TME) plays a major role in cancer progression. Therefore, understanding …
microenvironment (TME) plays a major role in cancer progression. Therefore, understanding …
High-throughput compound screening identifies navitoclax combined with irradiation as a candidate therapy for HPV-negative head and neck squamous cell …
K Tuomainen, A Hyytiäinen, A Al-Samadi, P Ianevski… - Scientific Reports, 2021 - nature.com
Conventional chemotherapeutic agents are nonselective, often resulting in severe side
effects and the development of resistance. Therefore, new molecular-targeted therapies are …
effects and the development of resistance. Therefore, new molecular-targeted therapies are …
Comparative analysis of vascular mimicry in head and neck squamous cell carcinoma: in vitro and in vivo approaches
Simple Summary Head and neck squamous cell carcinomas (HNSCCs) are common and
among the deadliest neoplasms worldwide, wherein metastasis represents the main cause …
among the deadliest neoplasms worldwide, wherein metastasis represents the main cause …
In vitro models as tools for screening treatment options of head and neck cancer
Various in vitro models using primary and established 2-and 3-dimensional cultures,
multicellular tumor spheroids, standardized tumor slice cultures, tumor organoids, and …
multicellular tumor spheroids, standardized tumor slice cultures, tumor organoids, and …