Anti‐tumor efficacy of a novel CLK inhibitor via targeting RNA splicing and MYC‐dependent vulnerability
K Iwai, M Yaguchi, K Nishimura… - EMBO molecular …, 2018 - embopress.org
The modulation of pre‐mRNA splicing is proposed as an attractive anti‐neoplastic strategy,
especially for the cancers that exhibit aberrant pre‐mRNA splicing. Here, we discovered that …
especially for the cancers that exhibit aberrant pre‐mRNA splicing. Here, we discovered that …
Clinical outcomes with ring sideroblasts and SF3B1 mutations in myelodysplastic syndromes: MDS clinical research consortium analysis
Y Migdady, J Barnard, N Al Ali, DP Steensma… - … Myeloma and Leukemia, 2018 - Elsevier
Background Recurrent somatic mutations in SF3B1 have been identified in patients with
myelodysplastic syndromes (MDS) and are associated with ring sideroblasts (RS) and …
myelodysplastic syndromes (MDS) and are associated with ring sideroblasts (RS) and …
Novel mutations in mitochondrial carrier family gene SLC25A38, causing congenital sideroblastic anemia in Iranian families, identified by whole exome sequencing
Sideroblastic anemias are heterogeneous rare hematological disorders, representing
diverse phenotypes. In this study, the genetic cause of congenital, transfusion dependent …
diverse phenotypes. In this study, the genetic cause of congenital, transfusion dependent …
[HTML][HTML] Alteration of SF3B1 and SRSF2 genes in myelodysplastic syndromes patients in upper northern Thailand
P Yimpak, A Tantiworawit… - Asian Pacific Journal …, 2019 - ncbi.nlm.nih.gov
Background: The frequency and pattern of mutation in SF3B1 and SRSF2 RNA splicing
machinery genes were found to vary among myelodysplastic syndrome (MDS) patients in …
machinery genes were found to vary among myelodysplastic syndrome (MDS) patients in …
[HTML][HTML] The frequency of SF3B1 mutations in Thai patients with myelodysplastic syndrome
P Rujirachaivej, T Siriboonpiputtana… - Asian Pacific Journal …, 2018 - ncbi.nlm.nih.gov
Genetic mutations in genes encoding critical component of RNA splicing machinery
including SF3B1 are frequently identified and recognized as the pathogenesis in the …
including SF3B1 are frequently identified and recognized as the pathogenesis in the …
New developments in the understanding and diagnosis of myelodysplastic syndromes with ring sideroblasts
LB Ribeiro, EV De Paula - Revista Brasileira de Hematologia e …, 2016 - SciELO Brasil
Myelodysplastic syndromes (MDS) represent a group of clonal hematopoietic stem cell
disorders in which cytopenias of variable severity are associated with dysplastic changes of …
disorders in which cytopenias of variable severity are associated with dysplastic changes of …