Flow processing offers many opportunities to optimize reactions in a rapid and automated
manner, yet often requires relatively large quantities of input materials. To combat this, the …

As organic chemistry becomes an increasingly data-rich field, there is a need for methods to
rapidly build and parameterize models for further development. We demonstrate the …

Reactor automation is revolutionising the way new chemical processes are discovered and
developed. Assigning repetitive aspects of chemical synthesis to machines, such as …

Although kinetic analysis has traditionally been conducted in a batch vessel, continuous-
flow aided kinetic analysis continues to swell in popularity. This can be partly attributed to …

Flow chemistry is having an increasing influence on manufacturing in the chemical industry,
but significant barriers remain in the development of these continuous processes. Dynamic …

The advent of transient flow methods has increased the efficiency and diversity of reaction
data collected through the collection of data series in a wider reaction space, beyond …

Currently, the development of flow processes is seen as a resource intensive and
specialized activity, when compared to batch processes. We describe an optimization …

Automated optimization in flow reactors is a technology that continues to gain interest in
academic and industrial research. For drug substance applications, where limited material is …

Aminations can be efficiently run, under plug flow conditions on water, catalyzed by low
levels of a recyclable palladium precatalyst. General protocols to couple amines, both aryl …

The implementation of self‐optimizing flow reactors has been mostly limited to model
reactions or known synthesis routes. In this work, a self‐optimizing flow photochemistry …