CircRNA: a novel type of biomarker for cancer

H Zhang, L Jiang, D Sun, J Hou, Z Ji - Breast cancer, 2018 - Springer
Circular RNAs (circRNAs) are a class of long, non-coding RNAs molecules that shape a
covalently closed continuous loop which have no 5′–3′ polarity and contain no polyA tail …

Circular RNAs are miRNA sponges and can be used as a new class of biomarker

FR Kulcheski, AP Christoff, R Margis - Journal of biotechnology, 2016 - Elsevier
Circular RNAs (circRNAs) are a class of non-coding RNAs (ncRNAs) that are involved in
transcriptional and posttranscriptional gene expression regulation. The development of …

[HTML][HTML] Circular RNA circNRIP1 acts as a microRNA-149-5p sponge to promote gastric cancer progression via the AKT1/mTOR pathway

X Zhang, S Wang, H Wang, J Cao… - Molecular …, 2019 - molecular-cancer.biomedcentral …
CircRNA has emerged as a new non-coding RNA that plays crucial roles in tumour initiation
and development.'MiRNA sponge'is the most reported role played by circRNAs in many …

[HTML][HTML] The circular RNA circDLG1 promotes gastric cancer progression and anti-PD-1 resistance through the regulation of CXCL12 by sponging miR-141-3p

DL Chen, H Sheng, DS Zhang… - Molecular …, 2021 - molecular-cancer.biomedcentral …
Dysregulation of circular RNAs (circRNAs) plays an important role in the development of
gastric cancer; thus, revealing the biological and molecular mechanisms of abnormally …

Loss of super-enhancer-regulated circRNA Nfix induces cardiac regeneration after myocardial infarction in adult mice

S Huang, X Li, H Zheng, X Si, B Li, G Wei, C Li… - Circulation, 2019 - Am Heart Assoc
Background: circRNAs (circular RNAs) are emerging as powerful regulators of cardiac
development and disease, but their roles in cardiac regeneration are still unknown. This …

Circular RNA_LARP4 inhibits cell proliferation and invasion of gastric cancer by sponging miR-424-5p and regulating LATS1 expression

J Zhang, H Liu, L Hou, GE Wang, R Zhang, Y Huang… - Molecular cancer, 2017 - Springer
Abstract Background Non-coding RNAs (ncRNAs) have been shown to regulate gene
expression involved in tumor progression of multiple malignancies. Our previous studies …

[HTML][HTML] Circular RNA circ-ITCH inhibits bladder cancer progression by sponging miR-17/miR-224 and regulating p21, PTEN expression

C Yang, W Yuan, X Yang, P Li… - Molecular …, 2018 - molecular-cancer.biomedcentral …
Circ-ITCH is a circRNA generated from several exons of itchy E3 ubiquitin protein ligase
(ITCH) and tumor suppressor served as a sponge for certain miRNAs targeting their parental …

ceRNA in cancer: possible functions and clinical implications

X Qi, DH Zhang, N Wu, JH Xiao, X Wang… - Journal of medical …, 2015 - jmg.bmj.com
Competing endogenous RNAs (ceRNAs) are transcripts that can regulate each other at post-
transcription level by competing for shared miRNAs. CeRNA networks link the function of …

Non-coding RNAs and potential therapeutic targeting in cancer

S Toden, TJ Zumwalt, A Goel - … et Biophysica Acta (BBA)-Reviews on …, 2021 - Elsevier
Recent advances have begun to clarify the physiological and pathological roles of non-
coding RNAs (ncRNAs) in various diseases, including cancer. Among these, microRNAs …

[HTML][HTML] Oncogenic role of fusion-circRNAs derived from cancer-associated chromosomal translocations

J Guarnerio, M Bezzi, JC Jeong, SV Paffenholz, K Berry… - Cell, 2016 - cell.com
Chromosomal translocations encode oncogenic fusion proteins that have been proven to be
causally involved in tumorigenesis. Our understanding of whether such genomic alterations …