Insect pest management in the age of synthetic biology

R Mateos Fernández, M Petek… - Plant Biotechnology …, 2022 - Wiley Online Library
Arthropod crop pests are responsible for 20% of global annual crop losses, a figure
predicted to increase in a changing climate where the ranges of numerous species are …

Foreign protein degradation and instability in plants and plant tissue cultures

PM Doran - Trends in biotechnology, 2006 - cell.com
Low production cost is a key factor driving the development of plants and plant tissue
cultures for the synthesis of therapeutic and other foreign proteins. Because product yield …

Preventing unintended proteolysis in plant protein biofactories

M Benchabane, C Goulet, D Rivard… - Plant biotechnology …, 2008 - Wiley Online Library
Numerous reports have been published over the last decade assessing the potential of
plants as useful hosts for the heterologous expression of clinically useful proteins …

Protein modifications in the plant secretory pathway: current status and practical implications in molecular pharming

L Faye, A Boulaflous, M Benchabane, V Gomord… - Vaccine, 2005 - Elsevier
Plants have become, over the last ten years, a suitable alternative to microbial and animal
cell factories for the production of clinically-useful, therapeutic proteins. Besides the well …

Prospects for using proteinase inhibitors to protect transgenic plants against attack by herbivorous insects

JA Gatehouse - Current Protein and Peptide Science, 2011 - ingentaconnect.com
Proteinase inhibitors which act on the digestive enzymes of insect herbivores are a basic
mechanism of plant defence. Attempts to exploit this defence mechanism in plant genetic …

Sea anemone venom: Ecological interactions and bioactive potential

C Menezes, NL Thakur - Toxicon, 2022 - Elsevier
This article provides a brief overview of the literature related to the chemical ecology of sea
anemones, focusing on their venom, and summarizing their bioprospecting potential. Sea …

In vivo and in vitro effect of Capsicum annum proteinase inhibitors on Helicoverpa armigera gut proteinases

VA Tamhane, NP Chougule, AP Giri, AR Dixit… - … et Biophysica Acta (BBA …, 2005 - Elsevier
Two proteinase inhibitors (PIs), CapA1 and CapA2, were purified from Capsicum annum
Linn. Var. Phule Jyoti leaves and assessed for their in vitro and in vivo activity against …

Plant platforms for efficient heterologous protein production

SB Ghag, VS Adki, TR Ganapathi, VA Bapat - … and Bioprocess Engineering, 2021 - Springer
Production of recombinant proteins is primarily established in cultures of mammalian, insect
and bacterial cells. Concurrently, concept of using plants to produce high-value …

High-level expression of the HIV-1 Pr55gag polyprotein in transgenic tobacco chloroplasts

N Scotti, F Alagna, E Ferraiolo, G Formisano… - Planta, 2009 - Springer
Plants have been recognized as a promising production platform for recombinant
pharmaceutical proteins. The human immunodeficiency virus Gag (Pr55 gag) structural …

Tackling unwanted proteolysis in plant production hosts used for molecular farming

MK Mandal, H Ahvari, S Schillberg… - Frontiers in plant …, 2016 - frontiersin.org
Although the field of molecular farming has significantly matured over the last years, some
obstacles still need to be resolved. A major limiting factor for a broader application of plant …