Structural plasticity and dynamic protein–protein interactions are critical determinants of
protein function within living systems. Quantitative chemical cross-linking with mass …

Knowledge of protein structure is crucial to our understanding of biological function and is
routinely used in drug discovery. High-resolution techniques to determine the three …

Biological systems have evolved to utilize proteins to accomplish nearly all functional roles
needed to sustain life. A majority of biological functions occur within the crowded …

Generating and analyzing overlapping peptides through multienzymatic digestion is an
efficient procedure for de novo protein using from bottom-up mass spectrometry (MS) …

Alzheimer's disease (AD) is a progressive neurological disorder featuring abnormal protein
aggregation in the brain, including the pathological hallmarks of amyloid plaques and …

The exploration of protein structure and function stands at the forefront of life science and
represents an ever‐expanding focus in the development of proteomics. As mass …

The profound effects of and distress caused by the global COVID-19 pandemic highlighted
what has been known in the health sciences a long time ago: that bacteria, fungi, viruses …

Protein–protein interactions (PPIs) are central in many biological processes but difficult to
characterize, especially in complex, unfractionated samples. Chemical cross-linking …

The complement system, a crucial part of the innate immune system, protects the human
body during bacterial infections. Complement comprises three pathways, classical, lectin …

Protein-protein interactions can be challenging to study yet provide insights into how
biological systems function. Targeted cross-linking mass spectrometry (TX-MS), a method …