Central mechanisms of glucose sensing and counterregulation in defense of hypoglycemia

S Stanley, A Moheet, ER Seaquist - Endocrine Reviews, 2019 - academic.oup.com
Glucose homeostasis requires an organism to rapidly respond to changes in plasma
glucose concentrations. Iatrogenic hypoglycemia as a result of treatment with insulin or …

Fuel not fun: Reinterpreting attenuated brain responses to reward in obesity

NB Kroemer, DM Small - Physiology & Behavior, 2016 - Elsevier
There is a well-established literature linking obesity to altered dopamine signaling and brain
response to food-related stimuli. Neuroimaging studies frequently report enhanced …

Striatal dopamine regulates systemic glucose metabolism in humans and mice

KW Ter Horst, NM Lammers, R Trinko… - Science translational …, 2018 - science.org
The brain is emerging as an important regulator of systemic glucose metabolism.
Accumulating data from animal and observational human studies suggest that striatal …

Glucose-sensing in the reward system

LL Koekkoek, JD Mul, SE La Fleur - Frontiers in neuroscience, 2017 - frontiersin.org
Glucose-sensing neurons are neurons that alter their activity in response to changes in
extracellular glucose. These neurons, which are an important mechanism the brain uses to …

The serotonergic system dysfunction in diabetes mellitus

Y Cai, X Li, H Zhou, J Zhou - Frontiers in Cellular Neuroscience, 2022 - frontiersin.org
Most peripheral serotonin (5-HT) is synthesized in enterochromaffin cells, and most
circulating 5-HT is stored in platelets. As a monoamine, 5-HT has several functions in …

Clinical presentation and diagnostic approach to hypoglycemia in adults without diabetes mellitus

G Palani, E Stortz, A Moheet - Endocrine Practice, 2023 - Elsevier
Objective To review the clinical presentation, causes, and diagnostic approach to
spontaneous hypoglycemia in adults without diabetes mellitus. Methods A literature review …

Gustatory perception alterations in obesity: an fMRI study

C Szalay, M Aradi, A Schwarcz, G Orsi, G Perlaki… - Brain research, 2012 - Elsevier
The background of feeding associated and metabolic diseases is not sufficiently understood
yet. Since gustatory alterations may be of particular significance in the above illnesses, in …

Spectro-spatial features in distributed human intracranial activity proactively encode peripheral metabolic activity

Y Huang, JB Wang, JJ Parker, R Shivacharan… - Nature …, 2023 - nature.com
Mounting evidence demonstrates that the central nervous system (CNS) orchestrates
glucose homeostasis by sensing glucose and modulating peripheral metabolism. Glucose …

Weighing the evidence: Variance in brain responses to milkshake receipt is predictive of eating behavior

NB Kroemer, X Sun, MG Veldhuizen, AE Babbs… - Neuroimage, 2016 - Elsevier
Variations in brain responses to sensory stimuli are typically considered to lack information
content and treated as “noise”. Alternatively, variable response patterns may reflect the …

Applying behavioral economics-based approaches to examine the effects of liquid sucrose consumption on motivation

JE Finnell, CR Ferrario - Appetite, 2023 - Elsevier
Overconsumption of sugar contributes to obesity in part by changing the activity of brain
areas that drive the motivation to seek out and consume food. Sugar-sweetened beverages …