Cytokines are critical in regulating immune responses and cellular behavior, playing dual
roles in both normal physiology and the pathology of diseases such as cancer. These …

Glioblastoma (GBM) is one of the most aggressive cancers of the brain. Despite extensive
research over the last several decades, the survival rates for GBM have not improved and …

Impaired type I interferons (IFNs) may cause immune deficiency in tumours. Current
supplementary IFN therapy partially restores anticancer immunity but simultaneously …

Glioblastoma (GBM) is the most aggressive and deadliest of the primary brain tumors,
characterized by malignant growth, invasion into the brain parenchyma, and resistance to …

Type I interferons (IFNs) are known for their key role in antiviral immune responses. In this
Review, we discuss accumulating evidence indicating that type I IFNs produced by …

Metastatic disease is the major cause of death from cancer, and immunotherapy and
chemotherapy have had limited success in reversing its progression. Data from mouse …

Infiltration by immune cells is a hallmark of most forms of malignancy. In this context, tumor-
associated macrophages (TAMs) represent key regulators of the complex interplay between …

Macrophages are myeloid immune cells that are strategically positioned throughout the
body tissues, where they ingest and degrade dead cells, debris, and foreign material and …

Macrophages are essential components of the inflammatory microenvironment of tumors.
Conventional treatment modalities (chemotherapy and radiotherapy), targeted drugs …

Targeted genome editing by artificial nucleases has brought the goal of site-specific
transgene integration and gene correction within the reach of gene therapy. However, its …