Clinical proton MR spectroscopy in central nervous system disorders

G Öz, JR Alger, PB Barker, R Bartha, A Bizzi, C Boesch… - Radiology, 2014 - pubs.rsna.org
A large body of published work shows that proton (hydrogen 1 [1H]) magnetic resonance
(MR) spectroscopy has evolved from a research tool into a clinical neuroimaging modality …

Huntington disease: natural history, biomarkers and prospects for therapeutics

CA Ross, EH Aylward, EJ Wild, DR Langbehn… - Nature Reviews …, 2014 - nature.com
Huntington disease (HD) can be seen as a model neurodegenerative disorder, in that it is
caused by a single genetic mutation and is amenable to predictive genetic testing, with …

Huntington disease: a single-gene degenerative disorder of the striatum

PC Nopoulos - Dialogues in clinical neuroscience, 2016 - Taylor & Francis
Huntington disease (HD) is an autosomal dominant, neurodegenerative disorder with a
primary etiology of striatal pathology. The Huntingtin gene (HTT) has a unique feature of a …

Proton and multinuclear magnetic resonance spectroscopy in the human brain at ultra-high field strength: A review

A Henning - Neuroimage, 2018 - Elsevier
Abstract Magnetic Resonance Spectroscopy (MRS) allows for a non-invasive and non-
ionizing determination of in vivo tissue concentrations and metabolic turn-over rates of more …

Magnetic resonance image example-based contrast synthesis

S Roy, A Carass, JL Prince - IEEE transactions on medical …, 2013 - ieeexplore.ieee.org
The performance of image analysis algorithms applied to magnetic resonance images is
strongly influenced by the pulse sequences used to acquire the images. Algorithms are …

Altered PDE10A expression detectable early before symptomatic onset in Huntington's disease

F Niccolini, S Haider, T Reis Marques, N Muhlert… - Brain, 2015 - academic.oup.com
There is an urgent need for early biomarkers and novel disease-modifying therapies in
Huntington's disease. Huntington's disease pathology involves the toxic effect of mutant …

Mitochondria and the brain: bioenergetics and beyond

P Belenguer, JMN Duarte, PF Schuck… - Neurotoxicity research, 2019 - Springer
The view of mitochondria acting solely as a powerhouse of the cell is no longer accurate.
Besides cell bioenergetics, primary targets of mitochondrial studies include their interplay …

Early white matter abnormalities, progressive brain pathology and motor deficits in a novel knock-in mouse model of Huntington's disease

J Jin, Q Peng, Z Hou, M Jiang, X Wang… - Human molecular …, 2015 - academic.oup.com
White matter abnormalities have been reported in premanifest Huntington's disease (HD)
subjects before overt striatal neuronal loss, but whether the white matter changes represent …

[HTML][HTML] Neuroimaging in Huntington's disease

F Niccolini, M Politis - World journal of radiology, 2014 - ncbi.nlm.nih.gov
Huntington's disease (HD) is a progressive and fatal neurodegenerative disorder caused by
an expanded trinucleotide CAG sequence in huntingtin gene (HTT) on chromosome 4. HD …

Proton magnetic resonance spectroscopy: relevance of glutamate and GABA to neuropsychology

G Ende - Neuropsychology review, 2015 - Springer
Abstract Proton Magnetic Resonance Spectroscopy (MRS) has been widely used to study
the healthy and diseased brain in vivo. The availability of whole body MR scanners with a …