Clinical proton MR spectroscopy in central nervous system disorders
A large body of published work shows that proton (hydrogen 1 [1H]) magnetic resonance
(MR) spectroscopy has evolved from a research tool into a clinical neuroimaging modality …
(MR) spectroscopy has evolved from a research tool into a clinical neuroimaging modality …
Huntington disease: natural history, biomarkers and prospects for therapeutics
CA Ross, EH Aylward, EJ Wild, DR Langbehn… - Nature Reviews …, 2014 - nature.com
Huntington disease (HD) can be seen as a model neurodegenerative disorder, in that it is
caused by a single genetic mutation and is amenable to predictive genetic testing, with …
caused by a single genetic mutation and is amenable to predictive genetic testing, with …
Huntington disease: a single-gene degenerative disorder of the striatum
PC Nopoulos - Dialogues in clinical neuroscience, 2016 - Taylor & Francis
Huntington disease (HD) is an autosomal dominant, neurodegenerative disorder with a
primary etiology of striatal pathology. The Huntingtin gene (HTT) has a unique feature of a …
primary etiology of striatal pathology. The Huntingtin gene (HTT) has a unique feature of a …
Proton and multinuclear magnetic resonance spectroscopy in the human brain at ultra-high field strength: A review
A Henning - Neuroimage, 2018 - Elsevier
Abstract Magnetic Resonance Spectroscopy (MRS) allows for a non-invasive and non-
ionizing determination of in vivo tissue concentrations and metabolic turn-over rates of more …
ionizing determination of in vivo tissue concentrations and metabolic turn-over rates of more …
Magnetic resonance image example-based contrast synthesis
The performance of image analysis algorithms applied to magnetic resonance images is
strongly influenced by the pulse sequences used to acquire the images. Algorithms are …
strongly influenced by the pulse sequences used to acquire the images. Algorithms are …
Altered PDE10A expression detectable early before symptomatic onset in Huntington's disease
There is an urgent need for early biomarkers and novel disease-modifying therapies in
Huntington's disease. Huntington's disease pathology involves the toxic effect of mutant …
Huntington's disease. Huntington's disease pathology involves the toxic effect of mutant …
Mitochondria and the brain: bioenergetics and beyond
The view of mitochondria acting solely as a powerhouse of the cell is no longer accurate.
Besides cell bioenergetics, primary targets of mitochondrial studies include their interplay …
Besides cell bioenergetics, primary targets of mitochondrial studies include their interplay …
Early white matter abnormalities, progressive brain pathology and motor deficits in a novel knock-in mouse model of Huntington's disease
White matter abnormalities have been reported in premanifest Huntington's disease (HD)
subjects before overt striatal neuronal loss, but whether the white matter changes represent …
subjects before overt striatal neuronal loss, but whether the white matter changes represent …
[HTML][HTML] Neuroimaging in Huntington's disease
F Niccolini, M Politis - World journal of radiology, 2014 - ncbi.nlm.nih.gov
Huntington's disease (HD) is a progressive and fatal neurodegenerative disorder caused by
an expanded trinucleotide CAG sequence in huntingtin gene (HTT) on chromosome 4. HD …
an expanded trinucleotide CAG sequence in huntingtin gene (HTT) on chromosome 4. HD …
Proton magnetic resonance spectroscopy: relevance of glutamate and GABA to neuropsychology
G Ende - Neuropsychology review, 2015 - Springer
Abstract Proton Magnetic Resonance Spectroscopy (MRS) has been widely used to study
the healthy and diseased brain in vivo. The availability of whole body MR scanners with a …
the healthy and diseased brain in vivo. The availability of whole body MR scanners with a …